| Litorin and litorin-albumin conjugate as effective regulators of body temperature in rats. | |
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MedLine Citation:
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PMID: 2132946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraperitoneal injection of the bombesin-like peptide litorin (0.5 ml of a 10(-5) M solution) led to a short-lived decrease in the body temperature (maximum of 0.9 degrees C) of laboratory rats. In contrast, immunization with litorin conjugated to bovine serum albumin (BSA) led to an increase in body temperature from 36.6 +/- 0.1 to 37.2 +/- 0.1 degrees C that persisted for at least 4 weeks and which was probably due to the binding of endogenous litorin by the newly formed antibody. These results suggest that litorin is involved in the physiological regulation of thermal homeostasis. The temperature of control rats immunized with Freund's adjuvant and BSA without litorin fluctuated around normal at 36.6 +/- 0.1 degrees C over this period. Rat body weight increased evenly during the experiment in both the experimental animals and the two control groups. However, the volume of food intake in the hour following 24 h food deprivation was lower in rats immunized with conjugated litorin than in the control groups. |
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Authors:
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A I Esakov; I P Ashmarin; O N Serova; M F Obukhova; Z I Storozheva; V P Golubovich; N V Kuznetsova |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical science Volume: 1 ISSN: 0955-9701 ISO Abbreviation: Biomed. Sci. Publication Date: 1990 |
Date Detail:
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Created Date: 1992-02-25 Completed Date: 1992-02-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9010320 Medline TA: Biomed Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 610-2 Citation Subset: IM |
Affiliation:
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Anokhin Institute of Physiology, Academy of Medical Sciences of the USSR, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Eating / drug effects Immunization Injections, Intraperitoneal Male Oligopeptides / pharmacology* Rats Serum Albumin, Bovine / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/Serum Albumin, Bovine; 0/litorin-albumin conjugate; 55749-97-8/litorin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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