| Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. | |
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MedLine Citation:
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PMID: 22894934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our studies revealed that LCA (lithocholic bile acid) extends yeast chronological lifespan if added to growth medium at the time of cell inoculation. We also demonstrated that longevity in chronologically aging yeast is programmed by the level of metabolic capacity and organelle organization that they developed before entering a quiescent state and, thus, that chronological aging in yeast is likely to be the final step of a developmental program progressing through at least one checkpoint prior to entry into quiescence. Here, we investigate how LCA influences longevity and several longevity-defining cellular processes in chronologically aging yeast if added to growth medium at different periods of the lifespan. We found that LCA can extend longevity of yeast under CR (caloric restriction) conditions only if added at either of two lifespan periods. One of them includes logarithmic and diauxic growth phases, whereas the other period exists in early stationary phase. Our findings suggest a mechanism linking the ability of LCA to increase the lifespan of CR yeast only if added at either of the two periods to its differential effects on various longevity-defining processes. In this mechanism, LCA controls these processes at three checkpoints that exist in logarithmic/diauxic, post-diauxic and early stationary phases. We therefore hypothesize that a biomolecular longevity network progresses through a series of checkpoints, at each of which (1) genetic, dietary and pharmacological anti-aging interventions modulate a distinct set of longevity-defining processes comprising the network; and (2) checkpoint-specific master regulators monitor and govern the functional states of these processes. |
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Authors:
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Michelle T Burstein; Pavlo Kyryakov; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Anna Leonov; Sean Levy; Forough Noohi; Vladimir I Titorenko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-08-16 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-18 Completed Date: 2013-02-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 3443-62 Citation Subset: IM |
Affiliation:
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Department of Biology, Concordia University,Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects Caloric Restriction Cell Nucleus / drug effects, genetics Cells, Cultured DNA, Fungal / metabolism DNA, Mitochondrial / metabolism Fatty Acids, Monounsaturated / pharmacology Glucose / pharmacology Lithocholic Acid / pharmacology* Longevity / drug effects Mitochondria / drug effects, genetics, metabolism Models, Biological Osmotic Pressure / drug effects Saccharomyces cerevisiae / cytology, drug effects*, growth & development* Stress, Physiological / drug effects Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal; 0/DNA, Mitochondrial; 0/Fatty Acids, Monounsaturated; 209B6YPZ4I/palmitoleic acid; 434-13-9/Lithocholic Acid; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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