| Lithocholic acid as a biomarker of intrahepatic cholestasis of pregnancy during ursodeoxycholic acid treatment. | |
| | |
MedLine Citation:
|
PMID: 19103957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The diagnosis and treatment of intrahepatic cholestasis of pregnancy (ICP) has important implications on fetal health. The biochemical parameter commonly used in the diagnosis of ICP is the determination of the concentration of total serum bile acids (TSBA). However, bile acid profile, especially lithocholic acid (LCA) analysis is a more sensitive and specific biomarker for differential diagnosis of this pathology and also could be an alternative to evaluate the efficiency of ursodeoxycholic acid (UDCA) for ICP treatment. METHODS: Serum bile acid (SBA) profiles including LCA determination, were studied in 28 ICP patients using a capillary electrophoresis method. The effects of UDCA treatment on bile acid profile, were analysed in 23 out of 28 ICP patients and the two samples obtained before and 15 days after treatment were compared. Two samples taken as controls were also obtained from each of five patients without therapy. RESULTS: A dramatic decrease in LCA concentrations and maintenance of TSBA concentrations were found in all patients after UDCA therapy, whereas SBA profiles together with LCA values did not change in patients without therapy. CONCLUSION: We propose LCA as an alternative biomarker and a more sensitive parameter than TSBA to evaluate the effectiveness of UDCA treatment, at least in ICP patients from Argentina. |
| | |
Authors:
|
Silvia E Lucangioli; Gustavo Castaño; Mario D Contin; Valeria P Tripodi |
Related Documents
:
|
4066077 - Bioavailability of indomethacin capsules in humans (ii): correlation with dissolution r... 8634807 - The combination of glycolic acid and hydroquinone or kojic acid for the treatment of me... 932557 - Synthesis of 11, 12-2h2- and 11, 12-3h2-labeled chenodeoxycholic and lithocholic acids. 736017 - Effect of cholestyramine on bile acid kinetics in patients with portal cirrhosis of the... 15562517 - Protonation of trimipramine salts of maleate, mesylate and hydrochloride observed by 1h... 23471347 - Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patie... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of clinical biochemistry Volume: 46 ISSN: 0004-5632 ISO Abbreviation: Ann. Clin. Biochem. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-23 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0324055 Medline TA: Ann Clin Biochem Country: England |
Other Details:
|
Languages: eng Pagination: 44-9 Citation Subset: IM |
Affiliation:
|
Cathedra of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Bile Acids and Salts / blood Cholestasis, Intrahepatic / blood, diagnosis*, drug therapy*, metabolism Female Humans Lithocholic Acid / diagnostic use* Liver Function Tests Pregnancy Ursodeoxycholic Acid / therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid; 434-13-9/Lithocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Appropriate laboratory utilization in diagnosing pulmonary embolism.
Next Document: Criteria for opiate identification using liquid chromatography linked to tandem mass spectrometry: p...