Document Detail

Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder.
MedLine Citation:
PMID:  17401045     Owner:  NLM     Status:  MEDLINE    
Bipolar disorder is associated with increased risk for dementia. We compared the prevalence of Alzheimer's disease between 66 elderly euthymic patients with bipolar disorder who were on chronic lithium therapy and 48 similar patients without recent lithium therapy. The prevalence of dementia in the whole sample was 19% v. 7% in an age-comparable population. Alzheimer's disease was diagnosed in 3 patients (5%) on lithium and in 16 patients (33%) who were not on lithium (P<0.001). Our case-control data suggest that lithium treatment reduced the prevalence of Alzheimer's disease in patients with bipolar disorder to levels in the general elderly population. This is in accordance with reports that lithium inhibits crucial processes in the pathogenesis of Alzheimer's disease.
Paula V Nunes; Orestes V Forlenza; Wagner F Gattaz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  190     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-07-24     Revised Date:  2008-04-29    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-60     Citation Subset:  IM    
Department and Institute of Psychiatry,Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
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MeSH Terms
Alzheimer Disease / prevention & control*
Antidepressive Agents / therapeutic use*
Bipolar Disorder / drug therapy*
Case-Control Studies
Lithium Compounds / therapeutic use*
Middle Aged
Risk Factors
Reg. No./Substance:
0/Antidepressive Agents; 0/Lithium Compounds
Comment In:
Br J Psychiatry. 2007 Oct;191:361; author reply 361-2   [PMID:  17906258 ]

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