Document Detail


Lithium inhibits carcinoid cell growth in vitro.
MedLine Citation:
PMID:  20589165     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Carcinoids are slow growing neuroendocrine tumors that often cause debilitating symptoms due to excessive secretion of hormones such as serotonin. Surgery is the only potentially curative treatment, but many patients have unresectable metastatic disease. Lithium is a non- competitive inhibitor of GSK-3 with an established safety profile. The objective of this study was to investigate the effects of lithium on carcinoid cell growth in vitro. Lithium treatment caused a dose-dependent reduction in carcinoid cancer cell (BON and H727) growth. Western blot analysis revealed increased expression of cleaved poly (ADP-ribose) polymerase (PARP), indicating the induction of apoptosis. Lithium treatment also suppressed cellular levels of serotonin and chromogranin A. In summary, lithium inactivates GSK-3, induces apoptosis, and suppresses carcinoid cancer cell growth in vitro. The drug has been used clinically since the 19(th) century to treat a variety of diseases including bipolar disorder, and its safety profile is well documented. Therefore, based on these findings, we have undertaken a clinical trial of lithium chloride in the treatment of patients with unresectable carcinoid cancer.
Authors:
David Yu Greenblatt; Mary Ndiaye; Herbert Chen; Muthusamy Kunnimalaiyaan
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Publication Detail:
Type:  Journal Article     Date:  2010-05-10
Journal Detail:
Title:  American journal of translational research     Volume:  2     ISSN:  1943-8141     ISO Abbreviation:  Am J Transl Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-08-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101493030     Medline TA:  Am J Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-53     Citation Subset:  -    
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 CA109053/CA/NCI NIH HHS; R01 CA109053-02/CA/NCI NIH HHS; R01 CA109053-03/CA/NCI NIH HHS; R01 CA121115/CA/NCI NIH HHS; R21 DK063015/DK/NIDDK NIH HHS; R21 DK063015-02/DK/NIDDK NIH HHS; R21 DK064735/DK/NIDDK NIH HHS; R21 DK064735-02/DK/NIDDK NIH HHS
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