Document Detail

Lithium-induced tremor treated with vitamin B6: a preliminary case series.
MedLine Citation:
PMID:  12075913     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The occurrence of tremor in patients receiving lithium is well known, but the management of this side effect is a significant problem both for patients and physicians. Although some reports have suggested that beta-blockers may be useful in treating lithium-induced tremor (LT), these agents have different side effects which limit the possibility of their use. Vitamin B6 has been reported to be effective in treatment of patients suffering from different kinds of neuroleptic-induced movement disorders including parkinsonism and tardive dyskinesia. METHODS: This report presents the results of a preliminary four-week open-label clinical trial of five patients who suffered from LT and who were treated with vitamin B6 (900-1200 mg/d). The severity of tremor was assessed using the tremor subscale from the Simpson-Angus Scale (SAS) and Subjective Clinical Improvement Impression scale (SCII). RESULTS: After the addition of vitamin B6 to their treatment, according to the SAS scores four patients showed an impressive improvement until total disappearance of tremor. The subjective scale, on which the patients' scored their impression of clinical improvement, showed similar results. None of the patients suffered from any side effects attributable to vitamin B6. CONCLUSIONS: The results suggest that vitamin B6 may alleviate LT, double-blind controlled trials are needed to establish this effect.
Chanoch Miodownik; Eliezer Witztum; Vladimir Lerner
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of psychiatry in medicine     Volume:  32     ISSN:  0091-2174     ISO Abbreviation:  Int J Psychiatry Med     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-21     Completed Date:  2003-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365646     Medline TA:  Int J Psychiatry Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Be'er-Sheva Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.
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MeSH Terms
Lithium / adverse effects*
Treatment Outcome
Tremor / chemically induced*,  drug therapy*
Vitamin B 6 / therapeutic use*
Reg. No./Substance:
7439-93-2/Lithium; 8059-24-3/Vitamin B 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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