| Lithium-induced inhibition of Na-K ATPase and Ca ATPase activities in rat brain synaptosome. | |
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MedLine Citation:
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PMID: 7598829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To explore the action mechanism of lithium in the brain, the author investigated the effects of lithium on Na-K ATPase and Ca ATPase in rat brain synaptosomes prepared from forebrains by the method of Booth and Clark. The activities of Na-K ATPase and Ca ATPase were assayed by the level of inorganic phosphate liberated from the hydrolysis of ATP. Lithium at the optimum therapeutic concentration of 1 mM decreased the activity of Na-K ATPase from the control value of 19.08 +/- 0.29 to 18.27 +/- 0.10 micromoles Pi/mg protein/h and also reduced the activity of Ca ATPase from 6.38 +/- 0.12 to 5.64 +/- 0.12 micromoles Pi/mg protein/h. The decreased activity of Na-K ATPase will decrease the rate of Ca2+ efflux, probably via an Na-Ca exchange mechanism and will increase the rate of Ca2+ entry by the depolarization of nerve terminals. The reduced activity of Ca ATPase will result in the decreased efflux of Ca2+. As a Conclusion, it can be speculated that lithium elevates the intrasynaptosomal Ca2+ concentration via inhibition of the activities of Na-K ATPase and Ca ATPase, and this increased [Ca2+]i will cause the release of neurotransmitters and neurological effects of lithium. |
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Authors:
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Y W Cho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Korean medical science Volume: 10 ISSN: 1011-8934 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: KOREA |
Other Details:
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Languages: eng Pagination: 7-13 Citation Subset: IM |
Affiliation:
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Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology* Calcium-Transporting ATPases / antagonists & inhibitors* Lithium / pharmacology* Male Rats Rats, Sprague-Dawley Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors* Synaptosomes / enzymology* |
| Chemical | |
Reg. No./Substance:
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7439-93-2/Lithium; EC 3.6.3.8/Calcium-Transporting ATPases; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Korean Med Sci Journal ID (pmc): jkms ISSN: 1011-8934 ISSN: 1598-6357 Publisher: Korean Academy of Medical Sciences |
Article Information Download PDF  Print publication date: Month: 2 Year: 1995 Volume: 10 Issue: 1 First Page: 7 Last Page: 13 ID: 3054122 PubMed Id: 7598829 |
| Lithium-induced inhibition of Na-K ATPase and Ca ATPase activities in rat brain synaptosome. | |
| Y. W. Cho | |
| Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea. |
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