Document Detail


Lithium increases tyrosine hydroxylase levels both in vivo and in vitro.
MedLine Citation:
PMID:  9523597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lithium, a simple monovalent cation, is the mainstay in the treatment of manic-depressive illness, but despite extensive research, its mechanism of action remains to be elucidated. Because lithium requires chronic administration for therapeutic efficacy and because its beneficial effects last well beyond its discontinuation, it has been postulated that lithium may exert major effects at the genomic level. We have previously shown that lithium, at therapeutically relevant concentrations, increases gene expression through the activator protein-1 (AP-1) transcription factor pathway in vitro. In the present study, we have sought to determine if lithium also increases the expression of endogenous genes known to be regulated by AP-1 and have therefore investigated the effects of lithium on tyrosine hydroxylase (TH) levels. Male Wistar rats were treated with LiCl for 9 days (subacute) or 4 weeks (chronic), and TH levels were measured in frontal cortex, hippocampus, and striatum using immunoblotting. Chronic (but not subacute) lithium treatment resulted in significant increases in TH levels in rat frontal cortex, hippocampus, and striatum. Lithium (1 mM) also increased TH levels in human SH-SY5Y neuroblastoma cells in vitro, indicating that lithium increases TH levels in both rodent and human tissues, likely via a direct cellular effect. These effects are compatible with (but likely not exclusively due to) an effect on the DNA binding of the 12-O-tetradecanoylphorbol 13-acetate response element to the AP-1 family of transcription factors.
Authors:
G Chen; P X Yuan; Y M Jiang; L D Huang; H K Manji
Related Documents :
12361807 - 4-hydroxynonenal induces glutamate cysteine ligase through jnk in hbe1 cells.
24666587 - Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver.
11950097 - Uva irradiation-induced activation of activator protein-1 is correlated with induced ex...
1590797 - Activin synergistically increased c-jun mrna in p19 embryonal carcinoma cells in the pr...
9526497 - Promoter recognition by a cyanobacterial rna polymerase: in vitro studies with the calo...
14759607 - All three isoforms of the voltage-dependent anion channel (vdac1, vdac2, and vdac3) are...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  70     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1768-71     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Corpus Striatum / drug effects,  enzymology
Frontal Lobe / drug effects,  enzymology
Hippocampus / drug effects,  enzymology
Humans
Lithium / pharmacology*
Male
Rats
Rats, Wistar
Tumor Cells, Cultured
Tyrosine 3-Monooxygenase / metabolism*
Chemical
Reg. No./Substance:
7439-93-2/Lithium; EC 1.14.16.2/Tyrosine 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Activation of p38MAPK in microglia after ischemia.
Next Document:  Effects of human type 1alpha metabotropic glutamate receptor expression level on phosphoinositide an...