| Lithium in the mating response and cell cycle of Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 7818545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies with Li+, an inhibitor of phosphoinositide metabolism, demonstrated that an early response of Saccharomyces cerevisiae to a-factor pheromone was negatively affected by this cation. This was monitored by the production of beta-galactosidase from a reporter construct containing the promoter region of the yeast STE3 gene and the coding region of the E. coli LacZ gene. Growth and progression through the cell cycle were also affected by Li+ and analysis of budded/unbudded ratios revealed that Li+ caused yeast cells to arrest in G1. These data provide support for the role of inositol phosphates in the mating response and cell cycle of Saccharomyces cerevisiae. |
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Authors:
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B E Smith; D H O'Day; G A Proteau |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 206 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 401-7 Citation Subset: IM |
Affiliation:
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Department of Zoology, Erindale College, University of Toronto, Mississauga, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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drug effects Gene Expression / drug effects* Kinetics Lithium Chloride / pharmacology* Peptides / pharmacology* Pheromones / pharmacology* Potassium Chloride / pharmacology Saccharomyces cerevisiae / drug effects*, growth & development, physiology Sodium Chloride / pharmacology Time Factors Transcription, Genetic beta-Galactosidase / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Pheromones; 61194-02-3/mating factor; 7447-40-7/Potassium Chloride; 7447-41-8/Lithium Chloride; 7647-14-5/Sodium Chloride; EC 3.2.1.23/beta-Galactosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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