| Lithium clearance in man: effects of dietary salt intake, acute changes in extracellular fluid volume, amiloride and frusemide. | |
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MedLine Citation:
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PMID: 3690979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The effects of amiloride and frusemide on lithium clearance were studied during changes in dietary sodium chloride intake and during infusion of 0.9% NaCl in normal human volunteers. 2. Lithium and fractional lithium clearances were less on the low than on the high salt diet. Values for the medium salt diet were intermediate. Acute extracellular fluid volume expansion with 0.9% NaCl infusion and extracellular fluid volume contraction 3-4 h after intravenous frusemide caused lithium and fractional lithium clearances to increase and decrease respectively. 3. Amiloride caused small changes in lithium and fractional lithium clearances on a low salt diet, but was without effect when salt intake was medium or high. 4. Increases in lithium clearance occurred immediately after frusemide irrespective of dietary salt intake and in subjects infused with 0.9% NaCl. Only in salt-depleted subjects did frusemide cause a substantial increase in fractional lithium clearance. Changes induced under other circumstances were small. 5. It is concluded that the lithium clearance method for assessment of proximal tubule salt and water reabsorption can be used with some degree of confidence in certain circumstances (medium and high salt intake as well as in acute volume expansion) but may not be reliable when dietary salt intake is low. |
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Authors:
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J C Atherton; R Green; S Hughes; V McFall; J A Sharples; L R Solomon; L Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 73 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-02-10 Completed Date: 1988-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 645-51 Citation Subset: IM |
Affiliation:
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Department of Physiological Sciences, University of Manchester, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amiloride / pharmacology* Creatinine / urine Extracellular Space / drug effects, metabolism Female Furosemide / pharmacology* Humans Lithium / pharmacokinetics*, urine Male Sodium / urine Sodium, Dietary / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 2609-46-3/Amiloride; 54-31-9/Furosemide; 60-27-5/Creatinine; 7439-93-2/Lithium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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