Document Detail

Lithium causing a serious sinus-node dysfunction at therapeutic doses.
MedLine Citation:
PMID:  6437719     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of lithium have been indexed in literature since 1900, most frequently in cases of intoxication. We recently studied the exceptional case of a patient showing a serious sinus node dysfunction during lithium treatment. The serum lithium levels were always within the therapeutic range. After two endocardial explorations and withdrawal of lithium, we found that the sinus node dysfunction was due to lithium and reversible after withdrawal of it. Some ignored dysfunctions could exist with a regularly controlled treatment.
G Montalescot; Y Levy; D Farge; L Brochard; B Fantin; C Arnoux; P Y Hatt
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  7     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-22     Completed Date:  1985-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-20     Citation Subset:  IM    
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MeSH Terms
Ajmaline / therapeutic use
Arrhythmia, Sinus / chemically induced*
Bipolar Disorder / drug therapy*
Bradycardia / chemically induced
Cardiac Pacing, Artificial
Lithium / adverse effects*,  therapeutic use
Lithium Carbonate
Middle Aged
Sinoatrial Node / drug effects*
Reg. No./Substance:
4360-12-7/Ajmaline; 554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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