Document Detail


Lithium administered by eye drops: a better treatment for bipolar affective disorder?
MedLine Citation:
PMID:  1862216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Bipolar affective patients are supersensitive to light. 2. Lithium treatment decreases retinal sensitivity to light. 3. Recent findings concerning lithium perturbation of the function of various members of the G proteins family including transducin (G1), as well as findings of lithium sensitive hyperactive G proteins in mononuclear leukocytes of patients with mania led to the hypothesis that lithium sensitive hyperfunctional G1 is responsible for the supersensitivity to light in affective patients. 4. Thus, a change in the usual route of lithium administration into eye drops delivery is hypothesized to be more efficient clinically, with the advantages of shortening the time delay necessary to achieve therapeutic effects, and having less systemic side effects and reduced toxicity.
Authors:
G Schreiber; S Avissar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-21     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Beer-Sheva Mental Health Center, Israel.
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MeSH Terms
Descriptor/Qualifier:
Bipolar Disorder / drug therapy*,  psychology
Humans
Lithium / administration & dosage*,  therapeutic use
Ophthalmic Solutions
Chemical
Reg. No./Substance:
0/Ophthalmic Solutions; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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