| Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow. | |
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MedLine Citation:
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PMID: 19171209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this literature review and meta-analysis was to determine what, if any, effects topical carbonic anhydrase inhibitors have on ocular hemodynamics in humans. A literature review and meta-analysis was conducted to investigate the effects of topical carbonic anhydrase inhibitors on ocular blood flow. Thirty-five articles were evaluated according to the inclusion criteria with 13 manuscripts meeting requirements for statistical analysis. Each study's effect size, defined as the change in blood flow measures after treatment with topical carbonic anhydrase inhibitors, was estimated using the weighted mean difference. Based on this meta-analysis, we conclude that topical carbonic anhydrase inhibitors increase ocular blood flow velocities in the retinal circulation, central retinal and short posterior ciliary arteries, but not in the ophthalmic artery. |
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Authors:
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Brent Siesky; Alon Harris; Edward Brizendine; Clarice Marques; Jennifer Loh; Joseph Mackey; Jennifer Overton; Peter Netland |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Survey of ophthalmology Volume: 54 ISSN: 0039-6257 ISO Abbreviation: Surv Ophthalmol Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404551 Medline TA: Surv Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 33-46 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Blood Flow Velocity / drug effects Carbonic Anhydrase Inhibitors / administration & dosage* Ciliary Arteries / physiology* Eye / blood supply* Glaucoma, Open-Angle / drug therapy, physiopathology* Humans Intraocular Pressure / drug effects Ophthalmic Solutions / administration & dosage* Regional Blood Flow / drug effects Retinal Artery / physiology* Ultrasonography, Doppler, Color |
| Chemical | |
Reg. No./Substance:
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0/Carbonic Anhydrase Inhibitors; 0/Ophthalmic Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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