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Literature-related discovery techniques applied to ocular disease: a vitreous restoration example.
MedLine Citation:
PMID:  24100365     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Literature-related discovery and innovation (LRDI) is a text mining approach for bridging unconnected disciplines to hypothesize radical discovery. Application to medical problems involves identifying key disease symptoms, and identifying causes and treatments for those symptoms from throughout the biomedical literature. LRDI has not been applied to vitreoretinal ophthalmological problems previously. This review illustrates the use of LRDI for potential restoration of degenerated vitreous.
RECENT FINDINGS: Vitreous restoration literature is very small; much research is aimed at vitreous composition and degradation, improving vitrectomy, and pharmacological vitreolysis. LRDI has the potential to find ways to slow, halt, or reverse the degradation through systemic improvement and myriad local treatments, some not ordinarily used by the ophthalmology community.
SUMMARY: The many potential discoveries and innovations were generated within a larger context, namely that timely healing required cause removal, healing obstacle removal, and healing acceleration (focused treatments) in an integrated manner. Although many potential causes, healing obstacles, and healing accelerations were identified strictly from the premier published literature, causes and obstacles that may have been operable but were not found in the literature were also postulated, as were gaps in the research that covered these potential causes and obstacles and unresearched treatments as well.
Authors:
Ronald N Kostoff; Leonoor I Los
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current opinion in ophthalmology     Volume:  24     ISSN:  1531-7021     ISO Abbreviation:  Curr Opin Ophthalmol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011108     Medline TA:  Curr Opin Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  606-610     Citation Subset:  -    
Affiliation:
aGeorgia Institute of Technology, School of Public Policy, Atlanta, Georgia, USA bDepartment of Ophthalmology, University Medical Center Groningen, University of Groningen cW.J. Kolff institute, Graduate School of Medical Sciences, University of Groningen, Groningen, the Netherlands.
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