Document Detail


Lisuride in Parkinson disease: efficacy of lisuride compared to levodopa.
MedLine Citation:
PMID:  7022259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lisuride hydrogen maleate, a semisynthetic ergoline and potent central dopamine and serotonin agonist, was tested in 10 patients with moderate to marked Parkinson disease whose response to levodopa had diminished. In the group of 10 patients, there was a significant reduction (p less than or equal to 0.05) in bradykinesia, gait disorder, and total Parkinson disease disability score when levodopa was replaced with lisuride. The mean dose of lisuride was 3.6 mg per day. Among the 10 patients, 5 were better on lisuride than on levodopa, and 4 continue on lisuride 1 year later. A decline in efficacy was noted in all four after a mean of 45 months. Adverse effects necessitating discontinuing the drug were mental changes in three patients and nausea in one patient. Lisuride, when used alone, has definite antiparkinsonian activity and is a promising new drug.
Authors:
A Lieberman; M Goldstein; A Neophytides; M Kupersmith; M Leibowitz; N Zasorin; R Walker; D Kleinberg
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  31     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  961-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Clinical Trials as Topic
Double-Blind Method
Ergolines / therapeutic use*
Female
Humans
Levodopa / therapeutic use*
Lisuride / adverse effects,  therapeutic use*
Male
Middle Aged
Parkinson Disease / diagnosis,  drug therapy*
Chemical
Reg. No./Substance:
0/Ergolines; 0/Levodopa; 18016-80-3/Lisuride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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