Document Detail


Listeria monocytogenes infection in patients with rheumatic diseases on TNF-alpha antagonist therapy: the Spanish Study Group experience.
MedLine Citation:
PMID:  19032819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The prognosis of patients with rheumatic diseases has improved considerably following the use of biological therapies. However, an increase in the frequency of bacterial infections has been observed in patients receiving these therapies. In the present study we aimed to assess the frequency of Listeria monocytogenes infection in a large series of patients with rheumatic diseases on treatment with tumor necrosis factor (TNF)-alpha blockers because of active disease refractory to conventional therapy, included in the Spanish Registry of Adverse Events of Biological Therapies in Rheumatic Diseases (BIOBADASER) of the Spanish Society for Rheumatology.
METHODS: Assessment of the incidence of infection due to Listeria monocytogenes in the Spanish Registry Study (BIOBADASER) per 1000 patient-years and 95% confidence intervals (95% CIs) was performed. Rate from this registry was compared with that from the general population in Europe and with the rate found in patients with rheumatoid arthritis (RA) from the Spanish Rheumatoid Arthritis Registry Cohort Study (EMECAR) that assessed morbidity and clinical expression of RA and included patients treated in most cases with conventional therapies.
RESULTS: Six patients on treatment with TNF-alpha antagonists were diagnosed as having Listeria monocytogenes infection. The incidence of this infection per 1000 patient-year (95% CI) was 0.256 (95% CI: 0.115-0.570). This was greater than the incidence observed in the general population from Europe and in the EMECAR study.
CONCLUSION: Despite the benefits associated to the use of TNF-alpha antagonists, a high level of surveillance is required to reduce the potential risk of infections related to the use of these drugs.
Authors:
J L Peña-Sagredo; M V Hernández; N Fernandez-Llanio; E Giménez-Ubeda; S Muñoz-Fernandez; A Ortiz; M A Gonzalez-Gay; M C Fariñas;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  26     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-04-08     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  854-9     Citation Subset:  IM    
Affiliation:
Divisions of Rheumatology and Infectious Diseases, Hospital Universitario Marques de Valdecilla, University of Cantabria, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal, Humanized
Cohort Studies
Female
Humans
Immunocompromised Host*
Immunologic Factors / adverse effects*,  immunology
Listeriosis / immunology*
Male
Middle Aged
Recombinant Fusion Proteins / adverse effects*,  immunology
Rheumatic Diseases / drug therapy*,  immunology
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Immunologic Factors; 0/Recombinant Fusion Proteins; 0/Tumor Necrosis Factor-alpha; 0/infliximab; FYS6T7F842/adalimumab
Investigator
Investigator/Affiliation:
Sara Marsal / ; Cristina Arnal Guimera / ; Laura Cebrian Mendez / ; Blanca Hernandez / ; Jose V Montes de Oca Mercader / ; Federico Navarro Sarabia / ; Francisco Javier Toyos De Miera / ; Isabel Garcia Bernal / ; Antonio Mera Varela / ; Gema Bonilla Hernan / ; Paloma Vela Cassempere / ; Olga Maiz / ; Estibaliz Barastay / ; Isidoro Gonzalez Alvaro / ; Rosario Garcia de Vicuna Pinedo / ; Ana Maria Ortiz Garcia / ; Sagrario Sanchez Andrada / ; Oscar Illera Martin / ; Antonio C Zea Mendoza / ; Paloma Garcia de la Pena Lefebvre / ; Marta Valero Exposito / ; Enrique Judez Navarro / ; Tomas Tinture Eguren / ; Eduardo Loza Cortina / ; Francisco Javier Manero Ruiz / ; Eugenio Gimenez Ruiz / ; Raimon Sanmarti Sala / ; Jose Ramon Rodriguez Cros / ; Juan D Canete / ; Carlos Rodriguez Lozano / ; Felix Francisco Hernandez / ; Inigo Rua Figueroa Fernandez / ; Maria Victoria Irigoyen Oyarzabal / ; Inmadulada Urena Garnica / ; Virginia Coret Cagigal / ; Jose Roman Ivorra / ; Inmaculada Chalmeta / ; Ana Cruz Valenciano / ; Manuel Crespo Echeverria / ; Felix Cabero Del Pozo / ; Carlos Marras Fernandez-Cid / ; Luis Francisco Linares Ferran / ; Juan Moreno Morales / ; Rosa Rosello Pardo / ; Carlos Vazquez Galeano / ; Monica Fernandez Castro / ; Carlos Isasi Zaragoza / ; Jose Luis Andreu Sanchez / ; Juan Carlos Vesga Carasa / ; Eduardo Cuende Quintana / ; Carmen Idalgo Tenorio / ; Maria Angeles Matias de La Mano / ; Isabel Mateo Bernardo / ; Patricia Carreira Delgado / ; Rosa Gonzalez Crespo / ; Carmen Garcia Gomez / ; Oriol Codina / ; Jose Valverde Garcia / ; Jose Antonio Piqueras / ; Manuel Fernandez Prada / ; Javier Vidal Fuentes / ; Joan Maymo Guarch / ; Carolina Perez Garcia / ; Javier Calvo Catala / ; Cristina Campos / ; Isabel Ibero Diaz / ; Vega Jovani Casado / ; Raquel Martin Domenech / ; Trinidad Perez Sandoval / ; Jose Raul Noguera Pons / ; Francisco J Navarro Blasco / ; Juan Victor Tovar Beltran / ; Eduardo Rejon / ; Ramon Mazzucchelli / ; Javier Quiros Donate / ; Pedro Zarco Montejo / ; Manuel Rodriguez Gomez / ; Eduardo Collantes Estevez / ; M Carmen Castro Villegas / ; Juan Carlos Cobeta Garcia / ; Santiago Benito Urbina / ; J A Lopez Martin / ; Jose Angel Cabezas Lefler / ; Marta Larrosa Padro / ; Jordi Gratacos Masmitja / ; Enrique Casado / ; Maria Teresa Ruiz Jimeno / ; Jaime Calvo Alen / ; Ivan Ferraz Amaro / ; Tomas Gonzalez Garcia / ; Alberto Alvarez Pio / ; Jesus Ibanez Ruan / ; Juan Jose Garcia Borras / ; Inmaculada Calvo / ; Elena Ciruelo Monge / ; Eva Tomero Muriel / ; Olga Amengual / ; Elena Cuesta / ; Amalia Sanchez-Andrade Fernandez / ; Encarnacion Saiz Cuenca / ; Jose Galvez Munoz / ; Montserrat Centellas / ; Jordi Fiter Areste / ; Luis Espadaler Poch / ; Manel Pujol Busquets / ; Josep Granados Duran / ; Maria Teresa Bosque Peralta / ; Lucia Pantoja Zarza / ; Maria Valvanera Pinillos Aransay / ; Julia Garcia Consuegra / ; Rosa Merino Munoz / ; Javier Rivera Redondo / ; Teresa Gonzalez Hernandez / ; Vera Ortiz Santamaria / ; Alfredo Buisan Aguirre / ; Carlos Pascual Martin-Gamero / ; Carmen Torres / ; Montserrat Corteguera Coro / ; Javier Alegre Lopez / ; Bonifacio Alvarez Lario / ; Jose Luis Alonso Valdivielso / ; Julia Fernandez Melon / ; Jose Luis Cuadra / ; F Javier Paulino Tevar / ; Marcos Paulino Huertas / ; Xavier Arasa Fava / ; Jordi del Blanco Barnusell / ; Anna Martinez Cristobal / ; Pilar Trenor / ; Inmaculada Banegil / ; Angel Aragon Diez / ; Angel Garcia Aparicio / ; Emilia Aznar / ; Ricardo Gutierrez / ; Maria Francisca Pina Perez / ; Miquel Angel Belmonte Serrano / ; Juan Beltran Fabregat / ; Juan Jose Lerma / ; Jose Manuel Rodriguez Heredia / ; Angel Gallegos Cid / ; Jesus Garcia Arroba Munoz / ; Miguel Cantalejo Moreira / ; Alberto Alonso Ruiz / ; Esther Uriarte Itzazelaia / ; Mauricio Minguez Vega / ; Gaspart Panadero Tendero / ; Miguel Angel Abad Hernandez / ; Maria Torresano Andres / ; Francisco Perez Torres / ; Ana Urruticoechea Arana / ; Dolors Boquet Estruch / ; Jose Ivorra Cortes / ; Antonio Juan Mas / ; Inmaculada Ros Vilamajo / ; Cristina Medrano Le Quement / ; Alfonso Corrales Martinez / ; Jenaro Grana Gil / ; Saul Mario Gelman Aizen / ; Eugenio Chamizo Carmona / ; Gaspar Perez Lidon / ; Manuel Tenorio Martin / ; Jose Carlos Rosas Gomez de Salazar / ; Gregorio Santos Soler / ; Cristina Hidalgo Calleja / ; Jaime Fernandez Campillo / ; Rocio Gonzalez Molina / ; Victor Eliseo Quevedo Vila / ; Juan Pablo Valdazo De Diego / ; Isabel Rotes Mas / ; Roser Tuneu Valls / ; Gerardo Iglesias De La Torre / ; Josep Pujol / ; Rosario Ibanez Bosh / ; Ricardo Gutierrez Polo / ; Maria Concepcion Manteca / ; Natividad del Val del Amo /

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