| Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in heLa Cells. | |
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MedLine Citation:
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PMID: 20658471 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It has been demonstrated that many flavonoids possess a potent and broad spectrum of antitumor activity. Liquiritigenin is a flavanone extracted from Glycyrrhizae. This study investigated the effects of liquiritigenin on cell viability and apoptosis induction in human cervical carcinoma (HeLa) cells. The results show that liquiritigenin significantly suppressed cell proliferation in a dose- and time-dependent manner in HeLa cells. In addition, liquiritigenin promoted apoptosis in HeLa cells, evidenced by apoptotic morphological changes and Annexin-V binding. The apoptosis induction with liquiritigenin is associated with the up-regulation of p53 and Bax, along with down-regulation of Bcl-2 and survivin. Finally, examination of the mitochondrial pathway of apoptosis revealed that cytochrome c is released from mitochondria to cytosol, associated with the activation of caspase-9 and -3, and the cleavage of poly (ADP-ribose) polymerase (PARP). Overall, the results indicate that liquiritigenin induces apoptosis in part via the mitochondrial pathway, which is associated with p53 up-regulation, release of cytochrome c and elevated activity of caspase-9 and -3 in HeLa cells. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Changwei Liu; Yu Wang; Sirou Xie; Yijing Zhou; Xiangmei Ren; Xiaoting Li; Yunqing Cai |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 25 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Nutrition and Food Hygiene, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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