| Liquid ventilation: clinical experiences. | |
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MedLine Citation:
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PMID: 10360215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liquid breathing has been in the medical literature for nearly 80 years and has been proposed as a means of improving gas exchange in patients with acute respiratory failure since the 1970s. There are many potential clinical applications of perfluorochemical (PFC) liquids that span many specialties in medicine. The ability to lower surface tension directed the initial clinical focus on neonatal therapy in the treatment of respiratory distress syndrome. The first clinical trial of PFC ventilation was performed in neonates in 1989. Additional trials using LiquiVent, a medical-grade PFC liquid, were initiated in 1993 in infants, children, and adults with severe respiratory distress. Based on the results of several studies during this time, it was concluded that the technique of liquid ventilation seemed to be safe, improve lung function, and recruit lung volume in patients from these various populations. More than 100 patients from preterm neonates to elderly patients with respiratory distress have been studied. In general, patients experience improvement in lung function and oxygenation, without adverse events. The results of such trials are encouraging and suggest the feasibility of this technique in the neonate with severe respiratory failure requiring respiratory support. Limitations of the technique include a limited understanding of how it works and its effectiveness in different patient populations. It has also become evident that there is a need for additional diagnostic and therapeutic instrumentation to expedite its implementation in the intensive care environment. This article discusses clinical experiences with liquid ventilation and highlights the technical needs to facilitate its implementation in respiratory care management. |
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Authors:
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J S Greenspan; M R Wolfson; T H Shaffer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biomedical instrumentation & technology / Association for the Advancement of Medical Instrumentation Volume: 33 ISSN: 0899-8205 ISO Abbreviation: Biomed Instrum Technol Publication Date: 1999 May-Jun |
Date Detail:
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Created Date: 1999-08-02 Completed Date: 1999-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8905560 Medline TA: Biomed Instrum Technol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Jefferson Medical College, Philadelphia 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Child, Preschool Clinical Trials as Topic Fluorocarbons / administration & dosage*, chemistry Humans Infant Infant, Newborn Infant, Premature Life Support Care / methods Middle Aged Pulmonary Gas Exchange Respiration, Artificial / methods* |
| Chemical | |
Reg. No./Substance:
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0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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