Document Detail


Liquid-diet with alcohol alters maternal, fetal and placental weights and the expression of molecules involved in integrin signaling in the fetal cerebral cortex.
MedLine Citation:
PMID:  21139874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal alcohol consumption during pregnancy causes wide range of behavioral and structural deficits in children, commonly known as Fetal Alcohol Syndrome (FAS). Children with FAS may suffer behavioral deficits in the absence of obvious malformations. In rodents, the exposure to alcohol during gestation changes brain structures and weights of offspring. The mechanism of FAS is not completely understood. In the present study, an established rat (Long-Evans) model of FAS was used. The litter size and the weights of mothers, fetuses and placentas were examined on gestation days 18 or 20. On gestation day 18, the effects of chronic alcohol on the expression levels of integrin receptor subunits, phospholipase-Cγ and N-cadherin were examined in the fetal cerebral cortices. Presence of alcohol in the liquid-diet reduced the consumption and decreased weights of mothers and fetuses but increased the placental weights. Expression levels of β(1) and α(3) integrin subunits and phospholipase-Cγ(2) were significantly altered in the fetal cerebral cortices of mothers on alcohol containing diet. Results show that alcohol consumption during pregnancy even with protein, mineral and vitamin enriched diet may affect maternal and fetal health, and alter integrin receptor signaling pathways in the fetal cerebral cortex disturbing the development of fetal brains.
Authors:
Ujjwal K Rout; Julie M Dhossche
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-17
Journal Detail:
Title:  International journal of environmental research and public health     Volume:  7     ISSN:  1660-4601     ISO Abbreviation:  Int J Environ Res Public Health     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-03-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101238455     Medline TA:  Int J Environ Res Public Health     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  4023-36     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. urout@umc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / drug effects*,  embryology,  metabolism*
Diet*
Ethanol / toxicity*
Female
Fetus / drug effects
Integrins / metabolism*
Organ Size / drug effects
Placenta / drug effects*
Pregnancy
Rats
Rats, Long-Evans
Signal Transduction*
Chemical
Reg. No./Substance:
0/Integrins; 64-17-5/Ethanol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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