Document Detail


Liquid crystalline coated drug particles as a potential route to long acting intravitreal steroids.
MedLine Citation:
PMID:  19534715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the potential for coating drug particles with liquid crystalline lipids with a view to modifying drug dissolution behaviour in the particle form. Firstly, dissolution of a simple salicylic acid layer on a microscope slide, as a model system was shown to be hindered by the liquid crystal layer and was sensitive to the type of liquid crystal nanostructure present. Particles of sodium salicylate (hydrophilic) and triamcinolone acetonide (hydrophobic) were produced, and lipids applied to the drug surface using either mechanofusion or co-spray drying approaches. The coated sodium salicylate particles dissolved extremely rapidly. Triamcinolone acetonide particles on the other hand dissolved very slowly compared to uncoated triamcinolone acetonide particles, which indicated that the coating was in fact intact, and that drug solubility in the aqueous channels likely controlled the transport of drug into the dissolution medium. Whilst more investigation is required, these initial studies demonstrate a potentially useful strategy for controlling drug dissolution for applications such as intravitreal steroid injections.
Authors:
Adam Tilley; David A V Morton; Tracey Hanley; Ben J Boyd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-01
Journal Detail:
Title:  Current drug delivery     Volume:  6     ISSN:  1875-5704     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208455     Medline TA:  Curr Drug Deliv     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  322-31     Citation Subset:  IM    
Affiliation:
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / chemistry
Chemistry, Pharmaceutical / methods
Crystallization
Delayed-Action Preparations
Hydrophobicity
Salicylic Acid / chemistry*
Sodium Salicylate / chemistry*
Solubility
Triamcinolone Acetonide / chemistry*
Vitreous Body / metabolism
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Delayed-Action Preparations; 54-21-7/Sodium Salicylate; 69-72-7/Salicylic Acid; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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