Document Detail

Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish.
MedLine Citation:
PMID:  20022329     Owner:  NLM     Status:  MEDLINE    
A comprehensive, sensitive and high-throughput liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry (LC-APPI-MS/MS) method has been developed for analysis of 36 halogenated flame retardants (HFRs). Under the optimized LC conditions, all of the HFRs eluted from the LC column within 14min, while maintaining good chromatographic separation for the isomers. Introduction of the pre-heated dopant to the APPI source decreased the background noise fivefold, which enhanced sensitivity. An empirical equation was proposed to describe the relation between the ion intensity and dopant flow. The excellent on-column instrument detection limits averaged 4.7pg, which was similar to the sensitivity offered by gas chromatography-high-resolution mass spectrometry (GC-HRMS). This method was used to analyze a series of fish samples. Good agreement was found between the results for PBDEs from LC-APPI-MS/MS and GC-HRMS.
Simon Ningsun Zhou; Eric J Reiner; Chris Marvin; Terry Kolic; Nicole Riddell; Paul Helm; Frank Dorman; Michelle Misselwitz; Ian D Brindle
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Publication Detail:
Type:  Journal Article     Date:  2009-12-05
Journal Detail:
Title:  Journal of chromatography. A     Volume:  1217     ISSN:  1873-3778     ISO Abbreviation:  J Chromatogr A     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318488     Medline TA:  J Chromatogr A     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  633-41     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier B.V. All rights reserved.
Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, ON L2S 3A, Canada.
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MeSH Terms
Chromatography, Liquid / methods*
Flame Retardants / analysis*
Halogenated Diphenyl Ethers / analysis*
Linear Models
Photochemistry / methods
Reproducibility of Results
Sensitivity and Specificity
Tandem Mass Spectrometry / methods*
Water Pollutants, Chemical / analysis
Reg. No./Substance:
0/Flame Retardants; 0/Halogenated Diphenyl Ethers; 0/Water Pollutants, Chemical

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