| Liquid chromatographic resolution of gemifloxacin mesylate on a chiral stationary phase derived from crown ether. | |
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MedLine Citation:
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PMID: 12210509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new racemic fluoroquinolone antibacterial agent, gemifloxacin mesylate, has been successfully resolved on a chiral stationary phase (CSP) derived from (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. Compared to the Crownpak CR(+) column, the CSP used in this study was more effective for the resolution of racemic gemifloxacin mesylate, especially in terms of analytical time. The resolution of gemifloxacin mesylate enantiomers on the CSP was found to be dependent on the type and content of organic and acidic modifiers in the aqueous mobile phase and the column temperature. |
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Authors:
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Myung Ho Hyun; Sang Cheol Han; Yoon Jae Cho; Jong Sung Jin; Wonjae Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical chromatography : BMC Volume: 16 ISSN: 0269-3879 ISO Abbreviation: Biomed. Chromatogr. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2003-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610241 Medline TA: Biomed Chromatogr Country: England |
Other Details:
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Languages: eng Pagination: 356-60 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Pusan 609-735, Korea. mhhyun@pusan.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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analysis* Chromatography, High Pressure Liquid / methods* Ethers, Cyclic / chemistry* Fluoroquinolones* Naphthyridines / analysis* Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Ethers, Cyclic; 0/Fluoroquinolones; 0/Naphthyridines; 175463-14-6/gemifloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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