Document Detail

Liquid chromatographic direct resolution of beta-amino acids on a doubly tethered chiral stationary phase containing N--H amide linkage based on (+)-(18-crown-6)- 2,3,11,12-tetracarboxylic acid.
MedLine Citation:
PMID:  17614324     Owner:  NLM     Status:  MEDLINE    
A doubly tethered chiral stationary phase (CSP) prepared by bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to doubly tethered primary aminoalkyl silica gel was used for the resolution of various beta-amino acids. All the beta-amino acids tested were resolved quite well, the separation (alpha) and the resolution factors (RS) being in the ranges 1.34-2.09 and 2.52-7.45, respectively, with a mobile phase of methanol-water (50:50, v/v) containing 10 mM acetic acid. The chiral recognition efficiency of the doubly-tethered CSP was found to be generally superior to that of the corresponding singly-tethered CSP in the resolution of beta-amino acids. The chiral recognition behaviors for the resolution of beta-amino acids on the doubly tethered CSP were examined by varying the type and content of organic and acidic modifiers in the aqueous mobile phase and the column temperature.
Myung Ho Hyun; Yanci Song; Yoon Jae Cho; Hee Jung Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chirality     Volume:  20     ISSN:  0899-0042     ISO Abbreviation:  Chirality     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Chemistry, Pusan National University, Busan, Republic of Korea.
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MeSH Terms
Amides / chemistry
Amino Acids / chemistry*,  isolation & purification*
Chromatography, High Pressure Liquid / methods
Crown Ethers*
Indicators and Reagents
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Crown Ethers; 0/Indicators and Reagents; 119719-58-3/18-crown-6 2,3,11,12-tetracarboxylic acid

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