Document Detail


Liquid chromatographic direct resolution of beta-amino acids on a doubly tethered chiral stationary phase containing N--H amide linkage based on (+)-(18-crown-6)- 2,3,11,12-tetracarboxylic acid.
MedLine Citation:
PMID:  17614324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A doubly tethered chiral stationary phase (CSP) prepared by bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to doubly tethered primary aminoalkyl silica gel was used for the resolution of various beta-amino acids. All the beta-amino acids tested were resolved quite well, the separation (alpha) and the resolution factors (RS) being in the ranges 1.34-2.09 and 2.52-7.45, respectively, with a mobile phase of methanol-water (50:50, v/v) containing 10 mM acetic acid. The chiral recognition efficiency of the doubly-tethered CSP was found to be generally superior to that of the corresponding singly-tethered CSP in the resolution of beta-amino acids. The chiral recognition behaviors for the resolution of beta-amino acids on the doubly tethered CSP were examined by varying the type and content of organic and acidic modifiers in the aqueous mobile phase and the column temperature.
Authors:
Myung Ho Hyun; Yanci Song; Yoon Jae Cho; Hee Jung Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chirality     Volume:  20     ISSN:  0899-0042     ISO Abbreviation:  Chirality     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-05-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Department of Chemistry, Pusan National University, Busan, Republic of Korea. mhhyun@pusan.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Amides / chemistry
Amino Acids / chemistry*,  isolation & purification*
Chromatography, High Pressure Liquid / methods
Crown Ethers*
Indicators and Reagents
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Crown Ethers; 0/Indicators and Reagents; 119719-58-3/18-crown-6 2,3,11,12-tetracarboxylic acid

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