| Liquid-based papanicolaou tests in endometrial carcinoma diagnosis: performance, error root cause analysis, and quality improvement. | |
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MedLine Citation:
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PMID: 22261450 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent reports show that the sensitivity of endometrial carcinoma detection on liquid-based Papanicolaou (Pap) tests (88%) is considerably higher than that reported on conventional Pap smears (20%-30%), although few laboratories have corroborated these results. We performed a 5-year retrospective review of all liquid-based Pap tests (n = 69) in women who later were given a diagnosis of endometrial carcinoma, performed error root cause analysis, and developed quality improvement initiatives as a means of error reduction. The original and rescreened Pap test sensitivity rates for endometrial carcinoma were 31.9% and 59.3%, respectively. Root cause analysis showed that poor specimen quality and cognitive failures contributed to a false-negative error in 67% (18/27) and 59% (16/27), respectively, of all cases. System analysis showed that latent factors contributing to error included lack of redundant and educational systems. We conclude that system redesign of liquid-based Pap test screening processes has the potential to improve sensitivity in endometrial carcinoma diagnosis. |
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Authors:
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Sharon B Sams; Heather S Currens; Stephen S Raab |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 248-54 Citation Subset: AIM; IM |
Affiliation:
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Dept of Pathology, University of Colorado, 12605 E 16th Ave, Anschutz Inpatient Pavilion, Aurora, CO 80045. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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