| Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report. | |
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MedLine Citation:
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PMID: 15066709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An original liquid chromatography method with photodiode-array detection (DAD) is presented for the determination of strychnine in blood. This sensitive method allows the use of only 0.1 ml of sample. The strychnine was isolated from blood using a liquid-liquid extraction procedure and chloroquine as an internal standard. The limits of detection (LOD) and quantification were 0.06 and 0.5 mg/l, respectively. The recovery was 94% and the coefficients of variation (CV) ranged from 5.9 to 10.8%. A fatal case of strychnine poisoning is presented, with a lethal blood concentration of 25 mg/l. |
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Authors:
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Charlotte Duverneuil; Geoffroy Lorin de la Grandmaison; Philippe de Mazancourt; Jean-Claude Alvarez |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Forensic science international Volume: 141 ISSN: 0379-0738 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-06 Completed Date: 2004-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: 17-21 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, 104 Boulevard R. Poincaré, 92380 Garches, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimalarials Chloroquine Chromatography, High Pressure Liquid / methods* Forensic Medicine / methods* Gas Chromatography-Mass Spectrometry Humans Indicators and Reagents Male Poisoning / diagnosis Poisons / blood* Strychnine / blood*, poisoning* |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Indicators and Reagents; 0/Poisons; 54-05-7/Chloroquine; 57-24-9/Strychnine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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