Document Detail


Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report.
MedLine Citation:
PMID:  15066709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An original liquid chromatography method with photodiode-array detection (DAD) is presented for the determination of strychnine in blood. This sensitive method allows the use of only 0.1 ml of sample. The strychnine was isolated from blood using a liquid-liquid extraction procedure and chloroquine as an internal standard. The limits of detection (LOD) and quantification were 0.06 and 0.5 mg/l, respectively. The recovery was 94% and the coefficients of variation (CV) ranged from 5.9 to 10.8%. A fatal case of strychnine poisoning is presented, with a lethal blood concentration of 25 mg/l.
Authors:
Charlotte Duverneuil; Geoffroy Lorin de la Grandmaison; Philippe de Mazancourt; Jean-Claude Alvarez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  141     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, 104 Boulevard R. Poincaré, 92380 Garches, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimalarials
Chloroquine
Chromatography, High Pressure Liquid / methods*
Forensic Medicine / methods*
Gas Chromatography-Mass Spectrometry
Humans
Indicators and Reagents
Male
Poisoning / diagnosis
Poisons / blood*
Strychnine / blood*,  poisoning*
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Indicators and Reagents; 0/Poisons; 54-05-7/Chloroquine; 57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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