Document Detail


Liquid chromatography/photodiode array detection for determination of strychnine in blood: a fatal case report.
MedLine Citation:
PMID:  15066709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An original liquid chromatography method with photodiode-array detection (DAD) is presented for the determination of strychnine in blood. This sensitive method allows the use of only 0.1 ml of sample. The strychnine was isolated from blood using a liquid-liquid extraction procedure and chloroquine as an internal standard. The limits of detection (LOD) and quantification were 0.06 and 0.5 mg/l, respectively. The recovery was 94% and the coefficients of variation (CV) ranged from 5.9 to 10.8%. A fatal case of strychnine poisoning is presented, with a lethal blood concentration of 25 mg/l.
Authors:
Charlotte Duverneuil; Geoffroy Lorin de la Grandmaison; Philippe de Mazancourt; Jean-Claude Alvarez
Related Documents :
6149299 - Gas chromatographic-mass spectrometric assay for the ultra-short-acting beta-blocker es...
19874649 - Comparison of oxycodone in vitreous humor and blood using emit screening and gas chroma...
23595799 - Controlling liquid spreading using microfabricated undercut edges.
3971589 - Volatile carboxylic acid profiling in physiological fluids: direct injection into a gas...
18980419 - Optimization of sample handling and processing for the carbon 13-labeled aminopyrine de...
4055949 - High-performance liquid chromatographic analysis of guanidino compounds using ninhydrin...
15679359 - Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha...
16846689 - Development of a cloud point extraction-spectrofluorimetric method for trace copper(ii)...
21859539 - Development and validation of stability indicating method for the determination of exem...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  141     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, 104 Boulevard R. Poincaré, 92380 Garches, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antimalarials
Chloroquine
Chromatography, High Pressure Liquid / methods*
Forensic Medicine / methods*
Gas Chromatography-Mass Spectrometry
Humans
Indicators and Reagents
Male
Poisoning / diagnosis
Poisons / blood*
Strychnine / blood*,  poisoning*
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Indicators and Reagents; 0/Poisons; 54-05-7/Chloroquine; 57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Micellar electrokinetic chromatographic screening method for common sexual assault drugs administere...
Next Document:  Simultaneous determination of thirteen beta-blockers and one metabolite by gradient high-performance...