Document Detail

Lipoxygenase inhibitory sphingolipids from Launaea nudicaulis.
MedLine Citation:
PMID:  22587795     Owner:  NLM     Status:  In-Data-Review    
Four new sphingolipids: nudicaulin A [(2S,3S,4R,14E)-2-{[octadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol; 1], nudicaulin B [(2S,3S,4R,14E)-2-{[(2R)-2-hydroxyoctadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol; 2], nudicaulin C [(2S,3S,4R,14E)-2-{[(2R)-2-hydroxyoctadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol-1-O-β-d-glucopyranoside; 3], and nudicaulin D [(2S,3S,4R)-2-{[(2R,3S,12E)-2,3-dihydroxyeicos-12-enoyl]amino}octadecane-1,3,4-triol; 4] together with 1-hexatriacontanol, β-sitosterol, octadecyl 4-hydroxycinnamate, elaidic acid, cholesta-5,22-diene-3,7-diol, oleanolic acid, apigenin, and β-sitosterol 3-O-β-d-glucopyranoside were isolated from the methanolic extract of the whole plant of Launaea nudicaulis. Their structures were elucidated using (1)H and (13)C NMR spectra and 2D NMR analyses (HMQC, HMBC, and COSY) in combination with mass spectrometry (EI-MS, HR-EI-MS, FAB-MS, and HR-FAB-MS) experiments and comparison with literature data of related compounds. Compounds 1-4 displayed moderate inhibitory potential against enzyme lipoxygenase in concentration-dependent manner with IC(50) value ranges 103-193 μM.
Naheed Riaz; Shehla Parveen; Muhammad Saleem; Muhammad Shaiq Ali; Abdul Malik; Muhammad Ashraf; Iftikhar Afzal; Abdul Jabbar
Related Documents :
21871815 - Increased concentrations of il-18 and uric acid in sickle cell anemia: contribution of ...
19525325 - A novel red clover hydroxycinnamoyl transferase has enzymatic activities consistent wit...
3349025 - Absolute configuration of cis-12-oxophytodienoic acid of flaxseed: implications for the...
24095985 - Effect of three-year consumption of erythritol, xylitol and sorbitol candies on various...
10805815 - Acute decrease in net glutamate uptake during energy deprivation.
9715355 - A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  14     ISSN:  1477-2213     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-54     Citation Subset:  IM    
a Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , 63100 , Bahawalpur , Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enhancing effects of different dosages of borneol on pharmacokinetics of salvanic acid B after oral ...
Next Document:  A new flavan-3-ol from Artocarpus nitidus subsp. lingnanensis.