| Lipoxygenase inhibitory sphingolipids from Launaea nudicaulis. | |
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MedLine Citation:
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PMID: 22587795 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Four new sphingolipids: nudicaulin A [(2S,3S,4R,14E)-2-{[octadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol; 1], nudicaulin B [(2S,3S,4R,14E)-2-{[(2R)-2-hydroxyoctadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol; 2], nudicaulin C [(2S,3S,4R,14E)-2-{[(2R)-2-hydroxyoctadecanoyl]amino}tetraeicos-14-ene-1,3,4-triol-1-O-β-d-glucopyranoside; 3], and nudicaulin D [(2S,3S,4R)-2-{[(2R,3S,12E)-2,3-dihydroxyeicos-12-enoyl]amino}octadecane-1,3,4-triol; 4] together with 1-hexatriacontanol, β-sitosterol, octadecyl 4-hydroxycinnamate, elaidic acid, cholesta-5,22-diene-3,7-diol, oleanolic acid, apigenin, and β-sitosterol 3-O-β-d-glucopyranoside were isolated from the methanolic extract of the whole plant of Launaea nudicaulis. Their structures were elucidated using (1)H and (13)C NMR spectra and 2D NMR analyses (HMQC, HMBC, and COSY) in combination with mass spectrometry (EI-MS, HR-EI-MS, FAB-MS, and HR-FAB-MS) experiments and comparison with literature data of related compounds. Compounds 1-4 displayed moderate inhibitory potential against enzyme lipoxygenase in concentration-dependent manner with IC(50) value ranges 103-193 μM. |
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Authors:
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Naheed Riaz; Shehla Parveen; Muhammad Saleem; Muhammad Shaiq Ali; Abdul Malik; Muhammad Ashraf; Iftikhar Afzal; Abdul Jabbar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 14 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 545-54 Citation Subset: IM |
Affiliation:
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a Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , 63100 , Bahawalpur , Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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