Document Detail


Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi.
MedLine Citation:
PMID:  15110694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition, 4-hydroxybenzoic acid 3, gallic acid 4 and methyl gallate 5 have also been reported for the first time from this species. Compounds 1 and 2 have displayed potent inhibitory potential against enzyme lipoxygenase in a concentration-dependent fashion with the IC(50) values 0.77 and 99.5 microM, along with ABTS(.+) radical quenching activity with IC(50) values of 147.5 and 498.2 microM, respectively.
Authors:
Naheed Riaz; Abdul Malik; Aziz-ur Rehman; Zaheer Ahmed; Pir Muhammad; Sarfraz Ahmad Nawaz; Juveria Siddiqui; Muhammad Iqbal Choudhary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytochemistry     Volume:  65     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1129-35     Citation Subset:  IM    
Affiliation:
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / chemistry,  isolation & purification,  pharmacology*
Dose-Response Relationship, Drug
Flavanones*
Flavonoids / pharmacology
Fruit / chemistry
Galactosides / chemistry,  isolation & purification,  pharmacology*
Inhibitory Concentration 50
Lipoxygenase Inhibitors / chemistry,  isolation & purification,  pharmacology*
Molecular Structure
Monoterpenes / chemistry,  isolation & purification,  pharmacology*
Nuclear Magnetic Resonance, Biomolecular
Paeonia / chemistry*
Plant Extracts / chemistry
Stilbenes / chemistry,  isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Flavanones; 0/Flavonoids; 0/Galactosides; 0/Lipoxygenase Inhibitors; 0/Monoterpenes; 0/Plant Extracts; 0/Stilbenes; 491-67-8/baicalein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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