| Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi. | |
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MedLine Citation:
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PMID: 15110694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition, 4-hydroxybenzoic acid 3, gallic acid 4 and methyl gallate 5 have also been reported for the first time from this species. Compounds 1 and 2 have displayed potent inhibitory potential against enzyme lipoxygenase in a concentration-dependent fashion with the IC(50) values 0.77 and 99.5 microM, along with ABTS(.+) radical quenching activity with IC(50) values of 147.5 and 498.2 microM, respectively. |
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Authors:
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Naheed Riaz; Abdul Malik; Aziz-ur Rehman; Zaheer Ahmed; Pir Muhammad; Sarfraz Ahmad Nawaz; Juveria Siddiqui; Muhammad Iqbal Choudhary |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytochemistry Volume: 65 ISSN: 0031-9422 ISO Abbreviation: Phytochemistry Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-27 Completed Date: 2004-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0151434 Medline TA: Phytochemistry Country: United States |
Other Details:
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Languages: eng Pagination: 1129-35 Citation Subset: IM |
Affiliation:
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International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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chemistry,
isolation & purification,
pharmacology* Dose-Response Relationship, Drug Flavanones* Flavonoids / pharmacology Fruit / chemistry Galactosides / chemistry, isolation & purification, pharmacology* Inhibitory Concentration 50 Lipoxygenase Inhibitors / chemistry, isolation & purification, pharmacology* Molecular Structure Monoterpenes / chemistry, isolation & purification, pharmacology* Nuclear Magnetic Resonance, Biomolecular Paeonia / chemistry* Plant Extracts / chemistry Stilbenes / chemistry, isolation & purification, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Flavanones; 0/Flavonoids; 0/Galactosides; 0/Lipoxygenase Inhibitors; 0/Monoterpenes; 0/Plant Extracts; 0/Stilbenes; 491-67-8/baicalein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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