Document Detail

Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol.
MedLine Citation:
PMID:  2494999     Owner:  NLM     Status:  MEDLINE    
Metabolism of resolved radioactive stereoisomer, [14C](+)-benzo-(a)pyrene-trans-7,8-dihydrodiol by highly purified soybean lipoxygenase plus linoleic acid was investigated. Trans-anti-7,8,9,10-tetrahydrotetrol, the product of hydrolytic breakdown of ultimate mutagenic benzo(a)pyrene-anti-7,8-dihydrodiol,9,10-epoxide, was detected as a major metabolite. The epoxidation, depended on the enzyme concentration and was inhibited by nordihydroguaiaretic acid. This study provides evidence on the ability of lipoxygenase to catalyze the epoxidation of benzo(a)pyrene-7,8-dihydrodiol.
J Z Byczkowski; A P Kulkarni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  159     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1199-205     Citation Subset:  IM    
Florida Toxicology Research Center, College of Public Health, University of South Florida, Tampa 33612.
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MeSH Terms
Chromatography, High Pressure Liquid
Dihydroxydihydrobenzopyrenes / metabolism*
Epoxy Compounds
Linoleic Acid
Linoleic Acids / metabolism
Lipoxygenase / metabolism*
Plants / enzymology*
Soybeans / enzymology
Reg. No./Substance:
0/Dihydroxydihydrobenzopyrenes; 0/Epoxy Compounds; 0/Linoleic Acids; 2197-37-7/Linoleic Acid; 24909-09-9/9,10-dihydro-9,10-dihydroxybenzo(a)pyrene; EC

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