Document Detail


Lipoxins and new lipid mediators in the resolution of inflammation.
MedLine Citation:
PMID:  16750421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoxins and aspirin-triggered lipoxins are lipid mediators generated from arachidonic acid that act to reduce inflammation and promote resolution. In addition, two new families of lipid mediators were uncovered, namely resolvins (resolution phase interaction products) and protectins, which derive from omega-3 polyunsaturated fatty acid. They possess potent anti-inflammatory, neuroprotective and pro-resolving properties. Eicosapentaenoic acid-derived mediators are denoted resolvins of the E series, and those biosynthesized from docosahexaenoic acid are resolvins of the D series (RvDs) and protectins. Aspirin impinges on these systems, triggering formation of the epimeric 17R-series RvDs--denoted as 'aspirin-triggered-RvDs'--which possess bioactivity in vivo equivalent to that evoked by their 17S-series counterparts (i.e. RvDs). These bioactive molecules open new avenues and approaches to therapeutic interventions via accelerated resolution of inflammation.
Authors:
Jan M Schwab; Charles N Serhan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-06-05
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  6     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-12     Completed Date:  2006-12-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
Affiliation:
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology,  therapeutic use
Arachidonic Acids / metabolism
Aspirin / pharmacology,  therapeutic use
Disease Models, Animal
Docosahexaenoic Acids / metabolism
Eicosapentaenoic Acid / analogs & derivatives,  metabolism
Humans
Inflammation / drug therapy,  metabolism*
Lipid Metabolism / drug effects
Lipoxins / metabolism*
Signal Transduction / drug effects
Grant Support
ID/Acronym/Agency:
P50-DE016191/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Arachidonic Acids; 0/Lipoxins; 0/lipoxin A4; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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