Document Detail


Lipoxin-induced migration of fish leukocytes.
MedLine Citation:
PMID:  1331277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The migration-inducing abilities of both synthetic lipoxin A4 (LXA4) and leukotriene B4 (LTB4) for rainbow trout neutrophils were examined with an in vitro assay. LXA4 caused enhanced migration of these cells with a three- to fourfold greater response than that observed toward LTB4 at most concentrations tested. Checkerboard assays showed that synthetic LXA4 was chemokinetic for trout leukocytes, while LTB4 was chemotactic. The chemokinetic ability of LX synthesized by rainbow trout macrophages maintained in short-term culture was also determined. These cells produced both 4-and 5-series LX, namely LXA4, LXA5, 11-trans-LXA4, 11-trans-LXA5, 7-cis-11-trans-LXA4 and 6(S)-LXA4. Although greater migration was found to LXA4 than to most of the other 4-series positional isomers, at least at some concentrations, this did not exhibit the degree of stereospecificity previously reported in some studies for mammalian leukocytes. Little difference was found between the chemokinetic responses of rainbow trout leukocytes to 4- and 5-series LX. These findings suggest that LXs are important migration-inducing molecules in trout and have a relatively long evolutionary history.
Authors:
G J Sharp; T R Pettitt; A F Rowley; C J Secombes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  51     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Aberdeen, Scotland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemotaxis, Leukocyte*
Hydroxyeicosatetraenoic Acids / pharmacology*
Kidney / cytology
Leukotriene B4 / pharmacology*
Lipoxins*
Macrophages / physiology
Neutrophils / physiology*
Salmon / physiology*
Chemical
Reg. No./Substance:
0/Hydroxyeicosatetraenoic Acids; 0/Lipoxins; 0/lipoxin A4; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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