| Lipotoxicity and the development of heart failure: moving from mouse to man. | |
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MedLine Citation:
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PMID: 21109186 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα-/- background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity. |
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Authors:
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William C Stanley; Fabio A Recchia |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell metabolism Volume: 12 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-03-02 Revised Date: 2013-03-07 |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 555-6 Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA. wstanley@medicine.umaryland.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P01 HL074237-07/HL/NHLBI NIH HHS; P20 HL101434-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2010 Oct;120(10):3443-54
[PMID:
20852389
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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