Document Detail

Liposteroid therapy for refractory seizures in children.
MedLine Citation:
PMID:  11063088     Owner:  NLM     Status:  MEDLINE    
Liposteroid is dexamethasone palmitate incorporated into liposomes and was developed as an anti-inflammatory drug for targeting therapy mainly for rheumatoid arthritis. Recently, it was reported that liposteroid might be effective for the treatment of West syndrome, with fewer side effects than those of corticotropin therapy. We describe three patients, a 2-month-old boy with early infantile epileptic encephalopathy, a 4-month-old girl with symptomatic West syndrome, and a 2-year-old girl with symptomatic localization-related epilepsy, whose refractory seizures were treated with liposteroid according to the original method reported by Yamamoto and colleagues in 1998. Uncontrollable seizures ceased completely in two patients and the seizure frequency decreased markedly in the other patient. Electroencephalograms revealed marked improvement in all patients. They showed no relapse of the seizures, and all showed no adverse effects except for mild brain shrinkage in one patient. Our experience with these three patients suggests that liposteroid therapy might be a new option for the treatment of refractory seizures in children, as well as for West syndrome.
H Yoshikawa; S Yamazaki; T Abe; Y Oda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  15     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  702-4     Citation Subset:  IM    
Department of Pediatrics, Niigata City General Hospital, Japan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Brain / radiography
Dexamethasone / therapeutic use*
Spasms, Infantile / diagnosis,  drug therapy*
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone

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