Document Detail


Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells.
MedLine Citation:
PMID:  21703989     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics aimed at reducing Aβ toxicity could be of clinical use for treatment of AD. Liposomes are suitable vehicles for therapeutic agents and imaging probes, and a promising way of targeting the various Aβ forms. We tested liposomes functionalized with phosphatidic acid, cardiolipin, or GM1 ganglioside, previously shown to have high Aβ-binding capacity. Mimicking Aβ-induced toxicity in mouse neuroblastoma cell lines, combined with administration of cell viability-modulating agents, we observed that functionalized liposomes rescued cell viability to different extents. We also detected rescue of the imbalance of GSK-3β and PP2A activity, and reduction in tau phosphorylation. Thus, these liposomes appear particularly suitable for implementing further therapeutic strategies for AD.
Authors:
Erika Bereczki; Francesca Re; Massimo E Masserini; Bengt Winblad; Jin Jing Pei
Related Documents :
21140179 - Fabrication and growth mechanism of zno nanostructures and their cytotoxic effect on hu...
10906779 - An mcm2-related gene is expressed in proliferating cells of intact and regenerating pla...
1316469 - Localization of cis-acting sequence requirements in the promoter of the latency-associa...
10458109 - Enhancement of borna disease virus transcription in persistently infected cells by seru...
22469629 - (18)f-fdg cell labeling may underestimate transplanted cell homing: more accurate, effi...
12808089 - Silencing of mouse aprt is a gradual process in differentiated cells.
1723609 - Rna synthesis in isolated rat osteoclasts: inhibitory effect of calcitonin.
17524049 - Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement t...
1213879 - Immunoglobulin secretion by mouse myeloma cells; involvement of an energy-requiring step.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-23
Journal Detail:
Title:  Nanomedicine : nanotechnology, biology, and medicine     Volume:  -     ISSN:  1549-9642     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233142     Medline TA:  Nanomedicine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gram-negative...
Next Document:  Cross-linked antioxidant nanozymes for improved delivery to CNS.