| Liposome-mediated delivery of oligodeoxynucleotides in vivo. | |
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MedLine Citation:
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PMID: 12396734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oligodeoxynuclotides (ODNs) are deoxyribonucleic-acid-based sequences showing therapeutic potential against such diseases as cancer, arteriosclerosis, arthritis, viral infections, and inflammation. Administration of these chemical entities using carriers has certain advantages over administration of free nucleic acid strands. Liposomes, one class of carriers, have been proven to be a popular choice for ODN delivery in vivo because of their potential to increase resistance of ODNs against nucleases and enhance circulation half-life. This result increases ODN uptake in target cells. Several liposomal formulations with proven potential for ODN delivery in vivo are discussed in this article. |
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Authors:
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Crispin R Dass |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drug delivery Volume: 9 ISSN: 1071-7544 ISO Abbreviation: Drug Deliv Publication Date: 2002 Jul-Sep |
Date Detail:
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Created Date: 2002-10-24 Completed Date: 2002-12-31 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9417471 Medline TA: Drug Deliv Country: England |
Other Details:
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Languages: eng Pagination: 169-80 Citation Subset: IM |
Affiliation:
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DNAzyme Technology, Johnson and Johnson Research, Strawberry Hills, Australia. cdass@medau.jnj.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Delivery Systems / methods* Humans Liposomes Oligodeoxyribonucleotides / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Oligodeoxyribonucleotides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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