| Liposomal nanomedicines as anticancer therapeutics: beyond targeting tumor cells. | |
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MedLine Citation:
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PMID: 18773947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor cells have long been the primary target cell type of liposomes for anticancer therapy. At present, it appears that tumor growth and metastasis is facilitated by interactions between tumor cells and supporting cells. These supporting cells consist of adaptive and innate immune cells, endothelial cells, pericytes, fibroblasts, stromal and mesenchymal cells. Insight into the activity of these cells and communication between these cells has provided new tactics for targeting alternative cell types in tumor treatment and offered new drug classes that could be used to modulate the activity of these supporting cells. Here, we provide an overview of liposomal systems that have been designed to target supporting cells in tumor tissue and therapeutic results of these systems. |
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Authors:
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Raymond M Schiffelers; Gert Storm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-08-19 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 364 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 258-64 Citation Subset: IM |
Affiliation:
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Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands. R.M.Schiffelers@uu.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage* Cell Communication Drug Delivery Systems* Humans Liposomes Nanoparticles / administration & dosage Neoplasms / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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