Document Detail


Liposomal methotrexate hydrogel for treatment of localized psoriasis: preparation, characterization and laser targeting.
MedLine Citation:
PMID:  19043379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Because systemic treatment of psoriasis is associated with several adverse effects, methotrexate (MTX), either topically or as targeted delivery, has become a more-interesting alternative. MATERIAL/METHODS: Methotrexate liposomes (LMTX) were prepared from DPPC, soy PC, egg yolk PC, and cholesterol. We studied the characterization, formulation of hydrogel (MTX 0.25%), and skin permeability, and compared LMTX gel with plain MTX gel and placebo for treating localized psoriasis in a double-blind study using albino mice. Gel formulations were applied daily, followed by irradiation with 80 joules from a 650-nm diode laser 3 times weekly for 12 weeks. Changes in disease signs and histopathological features were assessed. RESULTS: Drug release increased as laser energy increased following Higuchi's diffusion model and changed to zero order with energies > or = 80 J; significantly more MTX was released at all time intervals. Both LMTX and FMTX gels showed zero order kinetic release and antipsoriatic activity. During 8 months' follow-up, up to 60% of the patients treated with LMTX gel had no recurrence; this difference was statistically significant. No clinically significant changes were seen regarding blood or other laboratory variables. CONCLUSIONS: Application of an 80-J diode laser to 0.25% LMTX hydrogel was beneficial for relieving psoriasis and did not exert systemic toxicity.
Authors:
Maha Fadel Mohamed Ali; Manal Salah; Maha Rafea; Nadia Saleh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  14     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  PI66-74     Citation Subset:  IM    
Affiliation:
Department of Medical Laser Applications, National Institute of Laser Enhanced Sciences, Cairo University, Pharmaceutical Technology Unit, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Aged
Animals
Double-Blind Method
Female
Humans
Hydrogels*
Immunosuppressive Agents / administration & dosage*,  pharmacokinetics,  therapeutic use
Liposomes
Male
Methotrexate / administration & dosage*,  pharmacokinetics,  therapeutic use
Mice
Middle Aged
Placebos
Psoriasis / drug therapy*
Chemical
Reg. No./Substance:
0/Hydrogels; 0/Immunosuppressive Agents; 0/Liposomes; 0/Placebos; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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