| Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles. | |
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MedLine Citation:
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PMID: 6836294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The reticuloendothelial system of mice bearing EMT6 tumors was effectively blocked by intravenous injections of small unilamellar vesicles that incorporated a 6-aminomannose derivative of cholesterol in the lipid bilayer. Neutral liposomes loaded with indium-111-nitrilotriacetic acid were then injected. Fifty percent more radioactivity was deposited in tumors of the animals with blocked reticuloendothelial systems than in controls. Twenty-four hours after the injection of radioactive vesicles, well-defined tumor images were observed in whole-body gamma camera scintigraphs. Biodistribution studies showed that tumors from animals with blocked reticuloendothelial systems had more than twice the radioactivity per gram than any other tissue analyzed. |
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Authors:
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R T Proffitt; L E Williams; C A Presant; G W Tin; J A Uliana; R C Gamble; J D Baldeschwieler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 220 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 502-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Indium / diagnostic use Liposomes / administration & dosage*, diagnostic use Male Mice Mice, Inbred BALB C Mononuclear Phagocyte System / physiopathology* Neoplasm Transplantation Neoplasms / radionuclide imaging* Neoplasms, Experimental / radionuclide imaging Nitrilotriacetic Acid / diagnostic use Radioisotopes Radionuclide Imaging / methods |
| Grant Support | |
ID/Acronym/Agency:
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GM 21111-09A1/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Radioisotopes; 139-13-9/Nitrilotriacetic Acid; 7440-74-6/Indium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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