Document Detail

Liposomal amphotericin B does not induce nephrotoxicity or renal function impairment in premature neonates.
MedLine Citation:
PMID:  22633524     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Liposomal amphotericin B (LAMB) is frequently administered in NICU to preterm infants <1500 g at birth (VLBW) for treatment of systemic fungal infections (SFI). Concerns exist on safety and tolerability of such drug in patients who are at risk for renal function impairment due to their prematurity.
AIM: To assess the occurrence of renal function impairment related to LAMB in a 10-year cohort of VLBW neonates treated with this drug.
METHODS: Through database search of clinical charts, all VLBW neonates admitted to a 3(rd) level NICU in the years 1998-2007 and undergoing treatment with LAMB were identified. The occurrence of LAMB-attributable renal toxicity was investigated; infants withdrawn from treatment for development of adverse effects or toxicity were identified.
RESULTS: In the study period, 71 of 792 admitted VLBW neonates (8.9%) underwent antifungal treatment with LAMB administered at the recommended dosages (3-to-5 mg/kg/day). Mean duration of treatment was 14 (±9) days, mean cumulative dose given was 58 (±25) mg/kg per infant. Renal compromise, defined as hypokalaemia, and/or elevated creatinine serum levels, and/or decreased urine output, occurred in 2 of 71 (2.8%) treated patients, by 5 (±3) mean days after treatment initiation. In both patients LAMB was withdrawn; renal function impairment was only mild and transient, and normal renal function was restored at discharge. No other significant adverse effects were recorded in any treated neonate.
CONCLUSIONS: LAMB is generally safe and well tolerated in VLBW neonates. The occurrence of LAMB-related nephrotoxicity appears to be uncommon, mild and transient.
P Manzoni; P Galletto; S Rizzollo; C Franco; E Gallo; R Antonucci; V Fanos; D Farina
Related Documents :
11142434 - Sex ratio of transsexuals in germany: the development over three decades.
21942594 - Mother infant relationship and bonding myths and facts.
18599784 - Large and rapid melt-induced velocity changes in the ablation zone of the greenland ice...
19926224 - Eimeria macusaniensis associated lesions in neonate alpacas dying from enterotoxemia.
7370514 - The anterior fontanelle as an ultrasound window for study of the brain: a preliminary r...
24726604 - Neurodevelopmental outcomes after infant cardiac surgery with circulatory arrest and in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  88 Suppl 2     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-11-29     Revised Date:  2013-01-30    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S86-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Neonatology and NICU, Sant'Anna Hospital, Azienda Ospedaliera OIRM - S Anna, Torino, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphotericin B / adverse effects*,  therapeutic use*
Antifungal Agents / adverse effects*,  pharmacology,  therapeutic use
Candidiasis / drug therapy
Cohort Studies
Creatinine / blood
Fluconazole / therapeutic use
Hypokalemia / chemically induced
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight
Kidney / drug effects
Kidney Diseases / chemically induced*
Kidney Function Tests
Mycoses / drug therapy*
Premature Birth
Retrospective Studies
Sepsis / drug therapy
Reg. No./Substance:
0/Antifungal Agents; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B; 60-27-5/Creatinine; 86386-73-4/Fluconazole
Comment In:
Early Hum Dev. 2013 Jan;89(1):37   [PMID:  22831635 ]
Early Hum Dev. 2013 Jan;89(1):35-6   [PMID:  22877627 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gentle ventilation: the new evidence from the SUPPORT, COIN, VON, CURPAP, Colombian Network, and Neo...
Next Document:  Sepsis in young infants with congenital heart disease.