Document Detail


Liposomal amphotericin B (AmBisome) reduces dissemination of infection as compared with amphotericin B deoxycholate (Fungizone) in a rate model of pulmonary aspergillosis.
MedLine Citation:
PMID:  8877535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of AmBisome, a liposomal formulation of amphotericin B, was compared with that of Fungizone (amphotericin B desoxycholate), in a rat model of unilateral, pulmonary aspergillosis. Repeated administration of cyclophosphamide resulted in persistent, severe granulocytopenia. The left lung was inoculated with a conidial suspension of Aspergillus fumigatus, thus establishing an unilateral infection. Antifungal treatment was started 40 h after fungal inoculation, at which time mycelial disease was confirmed by histological examination. Both Fungizone 1 mg/kg and AmBisome 10 mg/kg resulted in increased survival in terms of delayed as well as reduced mortality. Quantitative cultures of lung tissue showed that only AmBisome 10 mg/kg resulted in reduction of the number of fungal cfus in the inoculated left lung. Compared with Fungizone, both AmBisome 1 mg/kg/day and AmBisome 10 mg/kg/day significantly prevented dissemination from the infected left lung to the right lung. In addition, both AmBisome regimens reduced hepatosplenic dissemination, and the 10 m/kg dosage fully prevented this complication. In conclusion, when compared with Fungizone, in this model AmBisome is more effective in reducing dissemination of unilateral, pulmonary aspergillosis, even when given in relatively low dosage. Such low dosages may have a place in prophylactic settings.
Authors:
A C Leenders; S de Marie; M T ten Kate; I A Bakker-Woudenberg; H A Verbrugh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  38     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215-25     Citation Subset:  IM    
Affiliation:
Department of Bacteriology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Agranulocytosis / chemically induced
Amphotericin B / administration & dosage,  therapeutic use*
Animals
Antifungal Agents / therapeutic use*
Aspergillosis / drug therapy*
Aspergillus fumigatus / drug effects
Deoxycholic Acid / therapeutic use*
Disease Models, Animal
Drug Combinations
Liposomes
Lung Diseases, Fungal / drug therapy*
Rats
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Drug Combinations; 0/Liposomes; 1397-89-3/Amphotericin B; 83-44-3/Deoxycholic Acid; 87687-70-5/amphotericin B, deoxycholate drug combination

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