Document Detail


Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association.
MedLine Citation:
PMID:  20205426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.
Authors:
Doralyn S Dalisay; Tim Quach; Tadeusz F Molinski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-24     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1524-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circular Dichroism
Liposomes / chemistry*
Molecular Conformation
Peroxides / chemistry*,  isolation & purification
Porifera / chemistry*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
AI039987/AI/NIAID NIH HHS; CA1225601/CA/NCI NIH HHS; R01 AI039987-12/AI/NIAID NIH HHS; R01 CA122256-04/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Liposomes; 0/Peroxides; 0/plakinic acid K; 0/plakinic acid L
Comments/Corrections
Erratum In:
Org Lett. 2011 Aug 5;13(15):4152

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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