Document Detail

Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model.
MedLine Citation:
PMID:  23344929     Owner:  NLM     Status:  Publisher    
PURPOSE: Although amiodarone is recognized as the most effective anti-arrhythmic drug available, it has negative hemodynamic effects. Nano-sized liposomes can accumulate in and selectively deliver drugs to ischemic/reperfused (I/R) myocardium, which may augment drug effects and reduce side effects. We investigated the effects of liposomal amiodarone on lethal arrhythmias and hemodynamic parameters in an ischemia/reperfusion rat model. METHODS AND RESULTS: We prepared liposomal amiodarone (mean diameter: 113 ± 8 nm) by a thin-film method. The left coronary artery of experimental rats was occluded for 5 min followed by reperfusion. Ex vivo fluorescent imaging revealed that intravenously administered fluorescent-labeled nano-sized beads accumulated in the I/R myocardium. Amiodarone was measurable in samples from the I/R myocardium when liposomal amiodarone, but not amiodarone, was administered. Although the intravenous administration of amiodarone (3 mg/kg) or liposomal amiodarone (3 mg/kg) reduced heart rate and systolic blood pressure compared with saline, the decrease in heart rate or systolic blood pressure caused by liposomal amiodarone was smaller compared with a corresponding dose of free amiodarone. The intravenous administration of liposomal amiodarone (3 mg/kg), but not free amiodarone (3 mg/kg), 5 min before ischemia showed a significantly reduced duration of lethal arrhythmias (18 ± 9 s) and mortality (0 %) during the reperfusion period compared with saline (195 ± 42 s, 71 %, respectively). CONCLUSIONS: Targeting the delivery of liposomal amiodarone to ischemic/reperfused myocardium reduces the mortality due to lethal arrhythmia and the negative hemodynamic changes caused by amiodarone. Nano-size liposomes may be a promising drug delivery system for targeting I/R myocardium with cardioprotective agents.
Hiroyuki Takahama; Hirokazu Shigematsu; Tomohiro Asai; Takashi Matsuzaki; Shoji Sanada; Hai Ying Fu; Keiji Okuda; Masaki Yamato; Hiroshi Asanuma; Yoshihiro Asano; Masanori Asakura; Naoto Oku; Issei Komuro; Masafumi Kitakaze; Tetsuo Minamino
Related Documents :
16837889 - Morphologic changes induced by oral long-term treatment with 8-prenylnaringenin in the ...
7956209 - Emergency contraception: a review.
8719439 - Growth hormone therapy in turner syndrome. analysis of long-term results.
7541769 - Dose-dependent responses in insulin-like growth factors, insulin-like growth factor-bin...
3028029 - Prevention of endometrial abnormalities.
14585519 - Impact of different progestins on endometrial vascularisation of postmenopausal women. ...
17451559 - Alcohol redirects cck-mediated apical exocytosis to the acinar basolateral membrane in ...
12787909 - Effect of 5-aminosalicylic acid on radiation-induced micronuclei in mouse bone marrow.
6529779 - Rifaximin (l/105), a new topical intestinal antibiotic: pharmacokinetic study after sin...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  -     ISSN:  1573-7241     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, 565-8565, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and...
Next Document:  Protective Effects of Hydrogen Sulfide Against Chronic Alcohol Intake-Induced Left Ventricular Remod...