Document Detail


Lipoproteins of varicella-zoster virus.
MedLine Citation:
PMID:  2155299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human fibroblast cells infected with varicella-zoster virus (VZV) showed a slight increase in lipoprotein synthesis, with the production of two major viral lipoproteins, as detected by radioimmunoprecipitation (RIP). Three bands of Mr 73,000, 90,000 and 97,000 were identified as forms of the VZV gpI glycoprotein. All three incorporated both palmitic and myristic acid, and were shown by thin-layer chromatography to contain myristic, palmitic and stearic acids. A very strong band corresponding to 7,000 Mr, which may represent the product of VZV gene 49, was detected after RIP and in VZV-infected cells, and was shown to contain almost entirely myristic acid. Several minor bands were also detected. The possible functions of the lipoproteins are discussed.
Authors:
D R Harper; H O Kangro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  71 ( Pt 2)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-06     Completed Date:  1990-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  459-63     Citation Subset:  IM    
Affiliation:
Department of Virology, Medical College, St. Bartholomew's Hospital, West Smithfield, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Chromatography, Thin Layer
Densitometry
Fatty Acids / analysis
Fibroblasts
Herpesvirus 3, Human / analysis*
Humans
Lipoproteins / analysis*,  biosynthesis
Radioimmunoprecipitation Assay
Viral Proteins / analysis*,  biosynthesis
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipoproteins; 0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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