Document Detail

Lipoproteins and protection of the arterial wall against infection: the "response to the threat of infection" hypothesis.
MedLine Citation:
PMID:  17331516     Owner:  NLM     Status:  MEDLINE    
The exact reason why lipoproteins are found in the arterial intima is not understood. On the basis of recent findings presented in the literature, we are proposing a hypothesis that the accumulation of lipoprotein in the arterial intima is originally a physiological process, part of our defences against infection designed to protect susceptible segments of the arterial wall from microbial invasion. In addition to the intrinsic antimicrobial activities of the deposited lipids, the formation of fibrin-based matrices within the intima is promoted, fibrinolysis is inhibited, the lipid content exerts a vasoconstrictive influence and smooth muscle cells are mobilised into the intima, all these phenomenons being instrumental in fighting off an infectious menace. Oxidized lipids (including oxysterols and lysophosphatidylcholine) resulting from the oxidation of lipoproteins close to sites of infection and inflammation are disseminated through the circulatory system and act as alarm signals at arterial walls, promoting the penetration and retention of lipoproteins in the intimal tissue of the most susceptible segments of the arterial network. Oxidized lipids in the intima constitute part of first-line antimicrobial defences and their presence acts as a signal to immune effector cells (notably macrophages and lymphocytes) which trigger the acquired immune response when foreign antigens are encountered.
H Le Brazidec
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Publication Detail:
Type:  Journal Article     Date:  2007-02-27
Journal Detail:
Title:  Atherosclerosis     Volume:  195     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-19     Completed Date:  2007-12-07     Revised Date:  2007-12-27    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e21-31     Citation Subset:  IM    
Centre Medical Charles De Gaulle, Department of Cardiology, 78 rue de Brement, 93130 Noisy le Sec, France.
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MeSH Terms
Arteries / microbiology,  pathology*
Coagulants / metabolism
Immune System / physiology*
Lipids / chemistry
Lipoproteins / chemistry,  metabolism*
Lysophosphatidylcholines / metabolism
Macrophages / metabolism
Models, Biological
Models, Theoretical
Myocytes, Smooth Muscle / metabolism
Sterols / chemistry,  metabolism
Th1 Cells / metabolism
Tunica Intima / pathology*
Reg. No./Substance:
0/Coagulants; 0/Lipids; 0/Lipoproteins; 0/Lysophosphatidylcholines; 0/Sterols

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