| Lipoproteins of the newborn rat. Reciprocal development of low density lipoproteins and apoprotein E-rich high density lipoproteins. | |
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MedLine Citation:
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PMID: 3204263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma lipids increase sharply with the onset of suckling in the neonatal rat. Much of the variation has been attributed to the high fat content of milk. Apoproteins AI, E and AIV were found in low concentrations in the fetus. They increased during suckling. Apoprotein E and apoprotein AIV did not exceed adult values whereas apoprotein AI concentration in the late suckling period was twice that of the adult. On the contrast, fetal apoprotein B was nearly 2.5-fold above adult concentration and was under the form of LDL, the main lipoprotein class in the late fetal period. Apoprotein B concentration decreased progressively as LDL was replaced by an apoprotein E-rich HDL. The latter class constituted an important transitory cholesterol carrier during the shift from the neonatal lipoprotein pattern dominated by LDL to the typical adult pattern in which HDL are predominant. Lack of active cholesterol ester transfer protein is believed to be one of the reasons for low LDL concentration in adult rats. However, in vitro incubation of radioactively-labelled HDL cholesteryl esters with rat plasma demonstrated that the juveniles' lipoprotein depleted plasma induced as little transfer of the label from HDL to lower density lipoproteins as that of the adult. Thus a transient cholesteryl ester transfer activity could not have contributed to the composition of the LDL pool in the fetus and the early suckling rat. It is more likely that LDL are secreted directly by the liver. Each apolipoprotein exhibited a characteristic developmental pattern different from that of adult rats fed hyperlipidic diets. It therefore appears that each apoprotein is controlled independently by a combination of programmed ontogenic development and nutritional factors leading to the progressive establishment of the adult lipoprotein profile. |
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Authors:
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M C Perrin Ansart; D Vacher; A Girard-Globa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of developmental physiology Volume: 10 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1989-02-09 Completed Date: 1989-02-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 321-34 Citation Subset: IM |
Affiliation:
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Centre de Recherches sur la Nutrition du CNRS, Meudon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Animals, Suckling Apolipoproteins A / blood Apolipoproteins B / blood Apolipoproteins E / blood* Centrifugation, Density Gradient Cholesterol Esters / blood Lipids / blood Lipoproteins, HDL / blood* Lipoproteins, LDL / blood* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Apolipoproteins B; 0/Apolipoproteins E; 0/Cholesterol Esters; 0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/apolipoprotein A-IV |
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