| Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. | |
| | |
MedLine Citation:
|
PMID: 22844248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with metabolic disease. However, precisely how lipoproteins affect tissue lipid composition has not been comprehensively analyzed. Here, we identify the major lipoproteins of Drosophila melanogaster and use genetics and mass spectrometry to study their assembly, interorgan trafficking, and influence on tissue lipids. The apoB-family lipoprotein Lipophorin (Lpp) is the major hemolymph lipid carrier. It is produced as a phospholipid-rich particle by the fat body, and its secretion requires Microsomal Triglyceride Transfer Protein (MTP). Lpp acquires sterols and most diacylglycerol (DAG) at the gut via Lipid Transfer Particle (LTP), another fat body-derived apoB-family lipoprotein. The gut, like the fat body, is a lipogenic organ, incorporating both de novo-synthesized and dietary fatty acids into DAG for export. We identify distinct requirements for LTP and Lpp-dependent lipid mobilization in contributing to the neutral and polar lipid composition of the brain and wing imaginal disc. These studies define major routes of interorgan lipid transport in Drosophila and uncover surprising tissue-specific differences in lipoprotein lipid utilization. |
| | |
Authors:
|
Wilhelm Palm; Julio L Sampaio; Marko Brankatschk; Maria Carvalho; Ali Mahmoud; Andrej Shevchenko; Suzanne Eaton |
Related Documents
:
|
18765848 - Behavior of feedlot cattle affects voluntary oral and physical interactions with manila... 7400058 - Use of feed additives to reduce ruminal methane production and deaminase activity in st... 12968688 - Effects of moisture, roller setting, and saponin-based surfactant on barley processing,... 12413098 - Effect of zinc source (zinc oxide vs zinc proteinate) and level on performance, carcass... 14988078 - Subcutaneous obesity is not associated with sympathetic neural activation. 3581838 - Sodium metabolism in wistar rats during a chronic high-salt or a low-protein diet: 22na... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-26 |
Journal Detail:
|
Title: PLoS genetics Volume: 8 ISSN: 1553-7404 ISO Abbreviation: PLoS Genet. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-07-30 Completed Date: 2013-01-04 Revised Date: 2013-03-14 |
Medline Journal Info:
|
Nlm Unique ID: 101239074 Medline TA: PLoS Genet Country: United States |
Other Details:
|
Languages: eng Pagination: e1002828 Citation Subset: IM |
Affiliation:
|
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apolipoproteins B / metabolism Biological Transport / genetics* Carrier Proteins / genetics, metabolism Diglycerides / metabolism Drosophila Proteins / metabolism Drosophila melanogaster* / genetics, metabolism Fat Body / metabolism Fatty Acids / metabolism Hemolymph / metabolism Imaginal Discs / metabolism Lipid Metabolism / genetics* Lipoproteins* / chemistry, genetics, metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins B; 0/Carrier Proteins; 0/Cv-d protein, Drosophila; 0/Diglycerides; 0/Drosophila Proteins; 0/Fatty Acids; 0/Lipoproteins; 0/lipid transfer protein; 0/lipophorin; 0/microsomal triglyceride transfer protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a...
Next Document: Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage comp...