Document Detail


Lipoproteins and cardiovascular disease: biological basis and epidemiological studies.
MedLine Citation:
PMID:  16674356     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
There is a long history to our understanding of the biological basis of lipoproteins in cardiovascular disease and to the key epidemiological studies in this field. Building on a wealth of laboratory evidence explaining the role of cholesterol and lipoproteins in the pathogenesis of atherosclerosis, epidemiological studies have characterized associations between serum lipid abnormalities and the risk of myocardial infarction. While elevation in total cholesterol has been associated with an increased risk of myocardial infarction, this information alone is not sufficient. To adequately predict cardiac risk, blood cholesterol must be further characterized by the high density lipoprotein (HDL) cholesterol present and the ratio of total cholesterol to HDL cholesterol. Several other factors, including such clinical syndromes as the "deadly quartet" of insulin resistance, central obesity, high triglycerides, and hypertension, are also associated with a markedly increased cardiac risk and should be identified; these may require unique therapeutic approaches. In addition to the costs of tertiary prevention and therapy after infarct, the impact of long-term morbidity and the economic consequences of this disease further emphasize the importance of optimizing current therapies and actual practice.
Authors:
W Castelli
Related Documents :
15828926 - Is lipoprotein (a)-apheresis useful?
24342316 - Aliskiren ameliorates sympathetic nerve sprouting and suppresses the inducibility of ve...
2705396 - European lipid guidelines: therapeutic recommendations. european atherosclerosis society.
16326226 - Hyperlipidemia.
19685516 - Echocardiography for determining the optimal atrioventricular interval in patients with...
12184966 - Aspirin prophylaxis in patients at low risk for cardiovascular disease: a systematic re...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research     Volume:  1     ISSN:  1098-3015     ISO Abbreviation:  Value Health     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  2006-05-05     Completed Date:  2006-05-25     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  100883818     Medline TA:  Value Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  -    
Affiliation:
Framingham Cardiovascular Institute, Framingham, MA 01702-9167, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Atherosclerosis, acute coronary events, and cholesterol-lowering: a new paradigm.
Next Document:  Landmark trials in lipid reduction.