Document Detail

Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease.
MedLine Citation:
PMID:  1537127     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several epidemiological studies have shown light-to-moderate alcohol consumption to have a net protective effect on the incidence of coronary heart disease (CHD). METHODS AND RESULTS: Major components of this effect, both positive and negative, may be explored using models that include both alcohol and variables expected to mediate the observed alcohol effect. Such modeling in a cohort of men of Japanese descent followed in the Honolulu Heart Program indicates that about half of the observed protection against CHD afforded by moderate alcohol consumption is mediated by an increase in high density lipoprotein cholesterol. An additional 18% of this protection is attributable to a decrease in low density lipoprotein cholesterol, but it is counterbalanced by a 17% increase in risk due to increased systolic blood pressure. The explanation for the residual 50% benefit attributable to alcohol is unknown but may include interference with thrombosis. The results in this population replicate those in the Lipid Research Clinics cohort studied earlier with the same analytic technique. CONCLUSIONS: The consistency of these findings across populations, along with the demonstration of reasonable biological pathways for this effect of alcohol, provides strong support for the hypothesis that light-to-moderate alcohol intake is protective against heart disease in men.
R D Langer; M H Criqui; D M Reed
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  85     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-27     Completed Date:  1992-03-27     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  910-5     Citation Subset:  AIM; IM    
Department of Community and Family Medicine, University of California San Diego 92093-0607.
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MeSH Terms
Alcohol Drinking*
Blood Pressure / physiology*
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Coronary Disease / epidemiology,  prevention & control*
Ethanol / pharmacology*
Hawaii / epidemiology
Japan / ethnology
Longitudinal Studies
Middle Aged
Proportional Hazards Models
Risk Factors
Grant Support
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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