| Lipoproteins of bacterial pathogens. | |
| | |
MedLine Citation:
|
PMID: 20974828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bacterial lipoproteins are a set of membrane proteins with many different functions. Due to this broad-ranging functionality, these proteins have a considerable significance in many phenomena, from cellular physiology through cell division and virulence. Here we give a general overview of lipoprotein biogenesis and highlight examples of the roles of lipoproteins in bacterial disease caused by a selection of medically relevant Gram-negative and Gram-positive pathogens: Mycobacterium tuberculosis, Streptococcus pneumoniae, Borrelia burgdorferi, and Neisseria meningitidis. Lipoproteins have been shown to play key roles in adhesion to host cells, modulation of inflammatory processes, and translocation of virulence factors into host cells. As such, a number of lipoproteins have been shown to be potential vaccines. This review provides a summary of some of the reported roles of lipoproteins and of how this knowledge has been exploited in some cases for the generation of novel countermeasures to bacterial diseases. |
| | |
Authors:
|
A Kovacs-Simon; R W Titball; S L Michell |
Related Documents
:
|
18636118 - Host-derived oxidized phospholipids and hdl regulate innate immunity in human leprosy. 19836838 - Testicular infection: microorganisms, clinical implications and host-pathogen interaction. 19416268 - Peptidoglycan induces loss of a nuclear peptidoglycan recognition protein during host t... 15597738 - Pseudomonas type iii effector avrpto suppresses the programmed cell death induced by tw... 10101968 - Chemokines and chemokine receptors in the cns: a possible role in neuroinflammation and... 18665908 - 14-3-3 epsilon antagonizes foxo to control growth, apoptosis and longevity in drosophila. |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-10-25 |
Journal Detail:
|
Title: Infection and immunity Volume: 79 ISSN: 1098-5522 ISO Abbreviation: Infect. Immun. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-24 Completed Date: 2011-03-15 Revised Date: 2011-08-03 |
Medline Journal Info:
|
Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
|
Languages: eng Pagination: 548-61 Citation Subset: IM |
Affiliation:
|
Room 416, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, United Kingdom EX4 4QD. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacteria
/
metabolism*,
pathogenicity Cell Membrane Gene Expression Regulation, Bacterial / physiology* Lipoproteins / genetics, physiology* Virulence |
| Chemical | |
Reg. No./Substance:
|
0/Lipoproteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal bar...
Next Document: Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for effi...