| Lipoprotein(a) stimulates the proliferation of cultured human arterial smooth muscle cells through two pathways. | |
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MedLine Citation:
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PMID: 8549783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of lipoprotein(a) (Lp(a)) on proliferation of human arterial smooth muscle cells (SMCs) and its mechanisms of action. Low density lipoprotein (LDL), Lp(a) and apolipoprotein(a) (apo(a)) significantly stimulated the proliferation of SMCs. Lp(a) and apo(a) reduced the amount of active transforming growth factor-beta (TGF-beta) with the mink lung epithelial cell bioassay, however LDL had no effect. Lp(a), but not apo(a), significantly stimulated the proliferation of SMCs even in the presence of a neutralizing antibody for TGF-beta. Our results suggest that Lp(a) stimulates the proliferation of SMCs via apo(a)-induced inhibition of TGF-beta activation and stimulation of SMCs by the LDL-particle of Lp(a). |
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Authors:
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M Miyata; S Biro; H Kaieda; H Tanaka |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 377 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-02-21 Completed Date: 1996-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 493-6 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins A
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pharmacology Arteries / cytology* Cell Division Cells, Cultured Dose-Response Relationship, Drug Humans Lipoprotein(a) / pharmacology* Lipoproteins, LDL / pharmacology Muscle Development Muscle, Smooth, Vascular / drug effects*, growth & development Transforming Growth Factor beta / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Lipoprotein(a); 0/Lipoproteins, LDL; 0/Transforming Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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