Document Detail


Lipoprotein(a) plasma concentrations, apolipoprotein (a) polymorphism and family history of coronary heart disease in patients with essential hypertension.
MedLine Citation:
PMID:  8836862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The purpose of the study was to investigate lipoprotein (a) (Lp(a)) levels and apolipoprotein (a) (apo(a)) phenotypes, and their relationship with a family history of coronary heart disease (CHD) in patients with essential hypertension (EH). METHODS: One hundred and eight newly diagnosed patients with mild to moderate EH and 159 controls were studied. Lp(a) levels were determined with an ELISA method. Apo(a) isoforms were identified by a capillary immunoblotting technique. RESULTS: Lp(a) levels and frequency distribution of apo(a) isoforms did not show significant differences between patients and controls. Lp(a) levels in hypertensives with a family history of CHD were significantly higher than in those without a family history of CHD (P < 0.01). Hypertensives with a family history of CHD showed significantly different frequencies of apo(a) isoforms to those without a family history of CHD (P < 0.05). In EH patients with a family history of CHD, apo(a) isoforms of low molecular weight (MW) had a higher prevalence (62.6%), while in hypertensives without a family history of CHD, apo(a) isoforms of high MW were prevalent (81.6%); the difference between the two subgroups was significant (P < 0.001). Multivariate analysis showed that both Lp(a) levels and apo(a) isoforms of low MW are significant variables in distinguishing between the subgroups. CONCLUSIONS: Lp(a) levels and apo(a) phenotypes do not differ between hypertensives and controls. High Lp(a) levels and apo(a) isoforms of low MW are strongly associated with a family history of CHD in hypertensives. The quantification of Lp(a) levels and the characterization of apo(a) phenotypes may be used for assessment of familial predisposition to CHD in hypertensives.
Authors:
C Gazzaruso; P Buscaglia; A Garzaniti; G Bonetti; S Savino; S Mariotti; A Jucci; G Finardi; D Geroldi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular risk     Volume:  3     ISSN:  1350-6277     ISO Abbreviation:  J Cardiovasc Risk     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-12-19     Completed Date:  1996-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9436980     Medline TA:  J Cardiovasc Risk     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Medical Therapeutics, First Medical Clinic, IRCCS Policlinico San Matteo, University of Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Apolipoproteins / genetics*
Apoprotein(a)
Blotting, Southern
Coronary Disease / blood,  complications,  genetics*
Electrophoresis, Gel, Pulsed-Field
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypertension / blood,  complications*
Lipoprotein(a) / blood*
Male
Middle Aged
Nuclear Family
Phenotype
Polymorphism, Genetic / genetics*
Regression Analysis
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Lipoprotein(a); EC 3.4.21.-/Apoprotein(a)

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